MOCS3

Gene Symbol	MOCS3
Entrez Gene	27304
Alt Symbol	UBA4
Species	Human
Gene Type	protein-coding
Description	molybdenum cofactor synthesis 3
Other Description	MPT synthase sulfurylase|UBA4, ubiquitin-activating enzyme E1 homolog|adenylyltransferase and sulfurtransferase MOCS3|molybdenum cofactor synthesis protein 3|molybdopterin synthase sulfurylase|ubiquitin-like modifier activating enzyme 4
Swissprots	O95396
Accessions	EAW75606 O95396 AF102544 AAC72412 AI942426 BC015939 AAH15939 BG105185 BQ188547 BY995583 DB452633 DQ892355 ABM83281 DQ895546 ABM86472 HY215239 NM_014484 NP_055299
Function	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:19017811}.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332}.
Top Pathways	Sulfur relay system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MOCS3 full length protein - ab162141 from Abcam Category Protein Source Wheat germ Species Human

MOCS3 Antibody Blocking Peptide - LS-E6510 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MOCS3 Protein - H00027304-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MOCS3-Antibody-N-term-Blocking-Peptide - BP19278a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MOCS3 - H00027304-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MOCS3 - H00027304-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human MOCS3, His-tagged - MOCS3-143H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Adenylyltransferase and sulfurtransferase MOCS3 (CBG01549) - CSB-YP014707CXX CSB-EP014707CXX CSB-BP014707CXX CSB-MP014707CXX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Caenorhabditis

Recombinant Human Adenylyltransferase and sulfurtransferase MOCS3(MOCS3) - CSB-YP014707HU CSB-EP014707HU CSB-BP014707HU CSB-MP014707HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Adenylyltransferase and sulfurtransferase MOCS3 (AAEL004607) - MBS1347742 from MyBioSource Category Protein Prices $1,965.00, $1,965.00, $2,430.00, $2,430.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Adenylyltransferase and sulfurtransferase MOCS3 (AGAP001737) - MBS1300025 from MyBioSource Category Protein Prices $1,975.00, $1,975.00, $2,440.00, $2,440.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Adenylyltransferase and sulfurtransferase MOCS3 (CBG01549) - MBS1112729 from MyBioSource Category Protein Prices $1,885.00, $1,885.00, $2,350.00, $2,350.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Caenorhabditis

Adenylyltransferase and sulfurtransferase MOCS3 (CPIJ001621) - MBS1162508 from MyBioSource Category Protein Prices $1,970.00, $1,970.00, $2,430.00, $2,430.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3) - MBS1030504 from MyBioSource Category Protein Prices $2,020.00, $2,020.00, $2,485.00, $2,485.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MOCS3 Protein - abx163863 from Abbexa Category Protein Species Human

MOCS3 - TP302099 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MOCS3 Recombinant Protein Antigen - NBP2-14244PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MOCS3 Peptide, Human - M34GP09636H from Creative Peptides Category Peptide Source Synthetic. Species Human

MOCS3 fusion protein - Ag26751 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

MOCS3 fusion protein - Ag26596 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

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