| Gene Symbol |
MOCS3
|
| Entrez Gene |
27304
|
| Alt Symbol |
UBA4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
molybdenum cofactor synthesis 3
|
| Other Description |
MPT synthase sulfurylase|UBA4, ubiquitin-activating enzyme E1 homolog|adenylyltransferase and sulfurtransferase MOCS3|molybdenum cofactor synthesis protein 3|molybdopterin synthase sulfurylase|ubiquitin-like modifier activating enzyme 4
|
| Swissprots |
O95396
|
| Accessions |
EAW75606 O95396 AF102544 AAC72412 AI942426 BC015939 AAH15939 BG105185 BQ188547 BY995583 DB452633 DQ892355 ABM83281 DQ895546 ABM86472 HY215239 NM_014484 NP_055299
|
| Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:19017811}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332}.
|
| Top Pathways |
Sulfur relay system
|