CD33

Gene Symbol	CD33
Entrez Gene	945
Alt Symbol	SIGLEC-3, SIGLEC3, p67
Species	Human
Gene Type	protein-coding
Description	CD33 molecule
Other Description	CD33 antigen (gp67)|gp67|myeloid cell surface antigen CD33|sialic acid binding Ig-like lectin 3|sialic acid-binding Ig-like lectin 3
Swissprots	F8WAL2 C9JEN7 Q8TD24 B4E3P8 P20138
Accessions	AAK83654 CAD36509 CCF76941 CCF76942 CDM22283 EAW71994 EAW71995 EAW71996 P20138 AK090470 BAC03451 AK293934 BAG57312 AK304810 BAG65560 AK309558 AW007749 AY162464 AAO26206 BC028152 AAH28152 BP295158 BP303860 CA426969 CA748646 DQ891726 ABM82652 DQ894903 ABM85829 M23197 AAA51948 XM_011527531 XP_011525833 XM_011527532 XP_011525834 XR_935875 NM_001082618 NP_001076087 NM_001177608 NP_001171079 NM_001772 NP_001763
Function	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). {ECO:0000269|PubMed:10556798, ECO:0000269|PubMed:11320212}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Monocytic/myeloid lineage cells.
Top Pathways	Hematopoietic cell lineage

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD33-Over-expression-Lysate - LY11166a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CD33 293T Cell Transient Overexpression Lysate(Denatured) - H00000945-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CD33 overexpression lysate - LY421195 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CD33 overexpression lysate - LY425947 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CD33 overexpression lysate - LY432863 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

Siglec-3/CD33 Overexpression Lysate (Denatured) - H00000945-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

CD33 (h): 293T Lysate - sc-114798 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CD33 (h3): 293T Lysate - sc-174842 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CD33 (h4): 293T Lysate - sc-174855 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Cynomolgus / Rhesus CD33 / Siglec-3 HEK293 Cell Lysate (WB positive control) - 90303-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human CD33 / Siglec-3 HEK293 Cell Lysate (WB positive control) - 12238-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CD33 / Siglec-3 HEK293 Cell Lysate (WB positive control) - 12238-H05HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CD33 Human Cells Transfected Lysate (positive control) (denatured) - orb174745 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human CD33 Human Cells Transfected Lysate (positive control) (denatured) - orb174682 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Siglec-3/CD33 Overexpression Lysate (Native) - NBP2-04204 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Siglec-3/CD33 Overexpression Lysate (Denatured) - H00000945-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human CD33 Knockdown Stable Cell Line - CSC-DC002740 from Creative biogene Category Cell Line Species Human

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