CD33

Gene Symbol	CD33
Entrez Gene	945
Alt Symbol	SIGLEC-3, SIGLEC3, p67
Species	Human
Gene Type	protein-coding
Description	CD33 molecule
Other Description	CD33 antigen (gp67)|gp67|myeloid cell surface antigen CD33|sialic acid binding Ig-like lectin 3|sialic acid-binding Ig-like lectin 3
Swissprots	F8WAL2 C9JEN7 Q8TD24 B4E3P8 P20138
Accessions	AAK83654 CAD36509 CCF76941 CCF76942 CDM22283 EAW71994 EAW71995 EAW71996 P20138 AK090470 BAC03451 AK293934 BAG57312 AK304810 BAG65560 AK309558 AW007749 AY162464 AAO26206 BC028152 AAH28152 BP295158 BP303860 CA426969 CA748646 DQ891726 ABM82652 DQ894903 ABM85829 M23197 AAA51948 XM_011527531 XP_011525833 XM_011527532 XP_011525834 XR_935875 NM_001082618 NP_001076087 NM_001177608 NP_001171079 NM_001772 NP_001763
Function	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). {ECO:0000269|PubMed:10556798, ECO:0000269|PubMed:11320212}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Monocytic/myeloid lineage cells.
Top Pathways	Hematopoietic cell lineage

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD33 CRISPR/Cas9 KO Plasmid (h) - sc-401011 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CD33 HDR Plasmid (h) - sc-401011-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CD33 Double Nickase Plasmid (h) - sc-401011-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CD33 Double Nickase Plasmid (h2) - sc-401011-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CD33 CRISPR Activation Plasmid (h) - sc-401011-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CD33 CRISPR Activation Plasmid (h2) - sc-401011-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CD33 Lentiviral Activation Particles (h) - sc-401011-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CD33 Lentiviral Activation Particles (h2) - sc-401011-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CD33 siRNA (h) - sc-42782 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CD33 shRNA Plasmid (h) - sc-42782-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CD33 shRNA (h) Lentiviral Particles - sc-42782-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Siglec-3/CD33 RNAi - H00000945-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Siglec-3/CD33 RNAi - H00000945-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU096741 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1121 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1121 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CD33 siRNA (Human) - CRH0667 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CD33 - MBS8209854 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CD33 (NM_001772.3) - SHH258989 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CD33(NM_001082618.1) - SHG156959 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CD33(NM_001772.3) - SHG156977 from Creative biogene Category siRNA Species Reactivities Human

Human CD33 siRNA - orb261169 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CD33 shRNA Plasmid (Human) - CHH0667 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CD33 miRNA 3'UTR clone - MiUTR1H-01867 from Creative biogene Species Reactivities Human

CD33 miRNA 3'UTR clone - MiUTR1H-01868 from Creative biogene Species Reactivities Human

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