CD33

Gene Symbol	CD33
Entrez Gene	945
Alt Symbol	SIGLEC-3, SIGLEC3, p67
Species	Human
Gene Type	protein-coding
Description	CD33 molecule
Other Description	CD33 antigen (gp67)|gp67|myeloid cell surface antigen CD33|sialic acid binding Ig-like lectin 3|sialic acid-binding Ig-like lectin 3
Swissprots	F8WAL2 C9JEN7 Q8TD24 B4E3P8 P20138
Accessions	AAK83654 CAD36509 CCF76941 CCF76942 CDM22283 EAW71994 EAW71995 EAW71996 P20138 AK090470 BAC03451 AK293934 BAG57312 AK304810 BAG65560 AK309558 AW007749 AY162464 AAO26206 BC028152 AAH28152 BP295158 BP303860 CA426969 CA748646 DQ891726 ABM82652 DQ894903 ABM85829 M23197 AAA51948 XM_011527531 XP_011525833 XM_011527532 XP_011525834 XR_935875 NM_001082618 NP_001076087 NM_001177608 NP_001171079 NM_001772 NP_001763
Function	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). {ECO:0000269|PubMed:10556798, ECO:0000269|PubMed:11320212}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Monocytic/myeloid lineage cells.
Top Pathways	Hematopoietic cell lineage

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD33 protein fragment - ab174052 from Abcam Category Protein Prices $414.00 Sizes 100 µg Source HEK 293 cells Species Human

Human CD33 full length protein - ab158054 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CD33 protein fragment - ab151885 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source HEK 293 cells Species Human

Human CD33 protein fragment - ab168690 from Abcam Category Protein Prices $630.00 Sizes 100 µg Source HEK 293 cells Species Human

CD33 Antibody Blocking Peptide - LS-E2506 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD33 Antibody Blocking Peptide - LS-E4004 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD33 Antibody Blocking Peptide - LS-E23007 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD33 Antibody Blocking Peptide - LS-E31197 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Siglec-3/CD33 Recombinant Protein - H00000945-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

Siglec-3/CD33 Recombinant Protein - H00000945-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Siglec-3/CD33 Peptide - P0593 from Novus Biologicals Category Peptide Species Human

CD33-Antibody-Center-Blocking-peptide - BP13541c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CD33-SIGLEC3-Antibody-N-term-Blocking-peptide - BP1622a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Siglec-3/CD33 Fc Chimera, CF - 1137-SL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human CD33 protein - orb49278 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human CD33 protein - orb138410 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human CD33 protein (His Tag) - orb138411 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

CD33 peptide - orb72243 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg Source This polypeptide is homologous to the Mouse , Rat protein.

CD33 protein (His tag) - 80R-3717 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

CD33 / SIGLEC3 (18-259, His-tag) - AR51404PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CD33 / SIGLEC3 (18-259, His-tag) - AR51404PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CD33 / SIGLEC3 - H00000945-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD33 / SIGLEC3 (Center) Control Peptide - AP55596CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CD33, Human, Recombinant - 19-C445 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

CD33,18-259aa Human, His tag, E.coli - 01-P2584 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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