STIM1

Gene Symbol STIM1
Entrez Gene 6786
Alt Symbol D11S4896E, GOK, IMD10, STRMK, TAM, TAM1
Species Human
Gene Type protein-coding
Description stromal interaction molecule 1
Other Description -
Swissprots E9PQJ4 Q13586 Q8N382
Accessions CAH05599 EAX02580 EAX02581 Q13586 AK057599 AK098480 AK310510 AK314928 BC019905 BC021300 AAH21300 BI820627 BM127091 CX873095 DQ895509 ABM86435 EU176341 ABW03792 HQ317451 ADO20317 JX014264 AFZ76986 U52426 AAC51627 NM_001277961 NP_001264890 NM_001277962 NP_001264891 NM_003156 NP_003147
Function Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628}.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules.
Tissue Specificity Ubiquitously expressed in various human primary cells and tumor cell lines. {ECO:0000269|PubMed:11004585, ECO:0000269|PubMed:11463338}.
Top Pathways Calcium signaling pathway

STIM1 (G555) Antibody - 4149 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using STIM1 (G555) Antibody.

STIM1 Antibody - 4916 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3, PC12 and COS cells using STIM1 Antibody.

STIM1 (D88E10) Rabbit mAb - 5668 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D88E10
Western blot analsyis of extracts from various cell lines using STIM1 (D88E10) Rabbit mAb.

Stim1 (A-8) - sc-166840 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Stim1 (A-8): sc-166840. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Stim1 (D-2) - sc-166541 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Stim1 (D-2): sc-166541. Western blot analysis of Stim1 expression in non-transfected: sc-117752 (A) and mouse Stim1 transfected: sc-127602 (B) 293T whole cell lysates.

Stim1 (F-2) - sc-393705 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Stim1 (F-2): sc-393705. Western blot analysis of Stim1 expression in non-transfected: sc-117752 (A) and mouse Stim1 transfected: sc-127602 (B) 293T whole cell lysates.

Stim1 (H-180) - sc-68897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Stim1 (H-180): sc-68897. Western blot analysis of Stim1 expression in non-transfected 293T: sc-117752 (A), human Stim1 transfected 293T: sc-171680 (B) and A-10 (C) whole cell lysates.

Stim1 (N-19) - sc-79106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Stim1 (N-19): sc-79106. Western blot analysis of Stim1 expression in non-transfected: sc-117752 (A) and human Stim1 transfected: sc-171959 (B) 293T whole cell lysates.

Stim1 (CDN3H4) - sc-66173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Stim1 (CDN3H4): sc-66173. Western blot analysis of Stim1 expression in Sol8 (A) and A-10 (B) whole cell lysates and rat thymus (C) and mouse thymus (D) tissue extracts.

Anti-Stromal interaction molecule 1 antibody - ab57834 from Abcam

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Stromal interaction molecule 1 antibody (ab57834) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human malignant lymphoma, diffuse large B.

Anti-Stromal interaction molecule 1 antibody - ab106531 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Stromal interaction molecule 1 antibody (ab106531) at 1 µg/mlLane 2 : Anti-Stromal interaction molecule 1 antibody (ab106531) at 2 µg/mlLane 1 : Mouse thymus tissue lysateLane 2 : Mouse thymus tissue lysate

Anti-Stromal interaction molecule 1 antibody - ab62031 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Stromal interaction molecule 1 antibody (ab62031) at 1 µg/mlLane 2 : Anti-Stromal interaction molecule 1 antibody (ab62031) at 2 µg/mlLane 1 : Mouse thymus tissue lysateLane 2 : Mouse thymus tissue lysateLysates/proteins at 15 µg per lane.

Anti-Stromal interaction molecule 1 antibody - ab86208 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Stromal interaction molecule 1 antibody - ab123595 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Stromal interaction molecule 1 by Western Blot of Immunprecipitate. anti-Stromal interaction molecule 1 antibody (recognizing a downstream epitope) at 1µg/ml staining Stromal interaction molecule 1 in HeLa whole cell lysate immunoprecipitated using ab123595 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 3 minutes.

Anti-Stromal interaction molecule 1 antibody [5A2] - ab119288 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5A2
ab119288 at 5 µg/ml staining Stromal interaction molecule 1 in Formalin-Fixed, Paraffin-Embedded Human Small Intestine tissue (submucosal plexus) by Immunohistochemistry.

Anti-Stromal interaction molecule 1 antibody [EPR3414] - ab108994 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3414
All lanes : Anti-Stromal interaction molecule 1 antibody [EPR3414] (ab108994) at 1/1000 dilutionLane 1 : SH SY5Y cell lysateLane 2 : K562 cell lysateLane 3 : HepG2 cell lysateLane 4 : HeLa cell lysateLane 5 : LnCaP cell lysateLysates/proteins at 10 µg per lane.Performed under reducing conditions.

Anti-Stromal interaction molecule 1 antibody - N-terminal - ab192766 from Abcam

Prices $376.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling Stromal interaction molecule 1 with ab192766 at a 5μg/mL.

Anti-GOK / STIM1 Antibody (aa600-685) - LS-C76130 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GOK / STIM1 Antibody (Extracellular Domain) - LS-C94908 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-GOK / STIM1 Antibody (C-Terminus) - LS-C91802 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GOK / STIM1 Antibody (C-Terminus, Biotin) - LS-C141689 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GOK / STIM1 Antibody (C-Terminus, DY650) - LS-C141690 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GOK / STIM1 Antibody (C-Terminus, DY488) - LS-C141691 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GOK / STIM1 Antibody (C-Terminus, HRP) - LS-C141692 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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