STIM1

Gene Symbol	STIM1
Entrez Gene	6786
Alt Symbol	D11S4896E, GOK, IMD10, STRMK, TAM, TAM1
Species	Human
Gene Type	protein-coding
Description	stromal interaction molecule 1
Other Description	-
Swissprots	E9PQJ4 Q13586 Q8N382
Accessions	CAH05599 EAX02580 EAX02581 Q13586 AK057599 AK098480 AK310510 AK314928 BC019905 BC021300 AAH21300 BI820627 BM127091 CX873095 DQ895509 ABM86435 EU176341 ABW03792 HQ317451 ADO20317 JX014264 AFZ76986 U52426 AAC51627 NM_001277961 NP_001264890 NM_001277962 NP_001264891 NM_003156 NP_003147
Function	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules.
Tissue Specificity	Ubiquitously expressed in various human primary cells and tumor cell lines. {ECO:0000269|PubMed:11004585, ECO:0000269|PubMed:11463338}.
Top Pathways	Calcium signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

STIM1 293T Cell Transient Overexpression Lysate(Denatured) - H00006786-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

STIM1 overexpression lysate - LY401099 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

STIM1 293 Cell Lysate - 401025 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

STIM1 Overexpression Lysate (Native) - NBL1-16538 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Stim1 (h): 293T Lysate - sc-171680 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Stim1 (h2): 293T Lysate - sc-171959 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

STIM1 Over-expression Lysate Product - GWB-143D27 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human STIM1 / GOK HEK293 Cell Lysate (WB positive control) - 11434-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human STIM1 Human Cells Transfected Lysate (positive control) (denatured) - orb173485 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

STIM1 Overexpression Lysate (Denatured) - H00006786-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

STIM1 Overexpression Lysate (Denatured) - H00006786-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human STIM1 Knockdown Stable Cell Line - CSC-DC015299 from Creative biogene Category Cell Line Species Human

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