STIM1

Gene Symbol	STIM1
Entrez Gene	6786
Alt Symbol	D11S4896E, GOK, IMD10, STRMK, TAM, TAM1
Species	Human
Gene Type	protein-coding
Description	stromal interaction molecule 1
Other Description	-
Swissprots	E9PQJ4 Q13586 Q8N382
Accessions	CAH05599 EAX02580 EAX02581 Q13586 AK057599 AK098480 AK310510 AK314928 BC019905 BC021300 AAH21300 BI820627 BM127091 CX873095 DQ895509 ABM86435 EU176341 ABW03792 HQ317451 ADO20317 JX014264 AFZ76986 U52426 AAC51627 NM_001277961 NP_001264890 NM_001277962 NP_001264891 NM_003156 NP_003147
Function	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules.
Tissue Specificity	Ubiquitously expressed in various human primary cells and tumor cell lines. {ECO:0000269|PubMed:11004585, ECO:0000269|PubMed:11463338}.
Top Pathways	Calcium signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Stromal interaction molecule 1 full length protein - ab78681 from Abcam Category Protein Source E. coli Species Human

Human Stromal interaction molecule 1 peptide - ab92678 from Abcam Category Peptide

Human Stromal interaction molecule 1 protein fragment - ab117174 from Abcam Category Protein Source E. coli Species Human

GOK / STIM1 Antibody Blocking Peptide - LS-E54 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GOK / STIM1 Antibody Blocking Peptide - LS-E26191 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GOK / STIM1 Antibody Blocking Peptide - LS-E30340 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GOK / STIM1 Antibody Blocking Peptide - LS-E16604 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STIM1 Blocking Peptide - NB110-60547PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

STIM1 Recombinant Protein - H00006786-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human STIM1 Protein - NBC1-18404 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

STIM1 Peptide - NBP1-76789PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

STIM1-Antibody-C-term-Blocking-peptide - BP10114b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STIM1 Protein (OPPA01769) - OPPA01769 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human STIM1 His tag protein - orb83852 from Biorbyt Category Protein Prices $323.00, $434.00 Sizes 50 μg, 100 μg Source Human Species Human

Human STIM1 protein - orb81389 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

STIM1 Blocking Peptide - 33R-4869 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Stromal Interaction Molecule 1 Peptide - AC21-1022-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

STIM1 / GOK (23-213, CaM-tag) - AR09085PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

STIM1 / GOK (23-213, CaM-tag) - AR09085PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

STIM1 / GOK - H00006786-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

STIM1 / GOK Control Peptide - AP30837CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Stromal Interaction Molecule 1, Human Recombinant - 228-11467-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human STIM1 - 228-11467-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human STIM1 - 228-11467-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

STIM1, 23-213aa, Human, CaM tagged, Recombinant, E.coli - 01-2052 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

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