STIM1

Gene Symbol	STIM1
Entrez Gene	6786
Alt Symbol	D11S4896E, GOK, IMD10, STRMK, TAM, TAM1
Species	Human
Gene Type	protein-coding
Description	stromal interaction molecule 1
Other Description	-
Swissprots	E9PQJ4 Q13586 Q8N382
Accessions	CAH05599 EAX02580 EAX02581 Q13586 AK057599 AK098480 AK310510 AK314928 BC019905 BC021300 AAH21300 BI820627 BM127091 CX873095 DQ895509 ABM86435 EU176341 ABW03792 HQ317451 ADO20317 JX014264 AFZ76986 U52426 AAC51627 NM_001277961 NP_001264890 NM_001277962 NP_001264891 NM_003156 NP_003147
Function	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules.
Tissue Specificity	Ubiquitously expressed in various human primary cells and tumor cell lines. {ECO:0000269|PubMed:11004585, ECO:0000269|PubMed:11463338}.
Top Pathways	Calcium signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human STIM1 gene - orb91948 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human STIM1 ORF clone(NM_003156.3) - CDCL186326 from Creative Biomart Species Human Accession NM_003156.3

Human STIM1 ORF clone(NM_003156.3) - CDCH402648 from Creative Biomart Species Human Accession NM_003156.3

Human STIM1 ORF Clone(NM_003156.3) - CDCL177306 from Creative Biomart Species Human Accession NM_003156.3

human STIM1 ORF clone - CDCH086834 from Creative Biomart Species Human Accession NM_003156

human STIM1 ORF clone - CDCH086835 from Creative Biomart Species Human Accession NM_003156

Human STIM1 Gene cDNA clone plasmid - HG11434-M from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid - HG11434-UT from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11434-CY from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11434-ACG from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11434-NH from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11434-CH from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11434-NF from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11434-NM from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11434-CF from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11434-CM from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11434-M-F from Sino Biological Species Human

Human STIM1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11434-M-N from Sino Biological Species Human Accession NM_003156.3

Human STIM1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11434-ACR from Sino Biological Species Human

Human STIM1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11434-NY from Sino Biological Species Human

Human STIM1 ORF clone(NM_003156.3) - CDCL186326 from Creative biogene Species Human

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