STIM1

Gene Symbol	STIM1
Entrez Gene	6786
Alt Symbol	D11S4896E, GOK, IMD10, STRMK, TAM, TAM1
Species	Human
Gene Type	protein-coding
Description	stromal interaction molecule 1
Other Description	-
Swissprots	E9PQJ4 Q13586 Q8N382
Accessions	CAH05599 EAX02580 EAX02581 Q13586 AK057599 AK098480 AK310510 AK314928 BC019905 BC021300 AAH21300 BI820627 BM127091 CX873095 DQ895509 ABM86435 EU176341 ABW03792 HQ317451 ADO20317 JX014264 AFZ76986 U52426 AAC51627 NM_001277961 NP_001264890 NM_001277962 NP_001264891 NM_003156 NP_003147
Function	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules.
Tissue Specificity	Ubiquitously expressed in various human primary cells and tumor cell lines. {ECO:0000269|PubMed:11004585, ECO:0000269|PubMed:11463338}.
Top Pathways	Calcium signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Stromal interaction molecule 1 (STIM1), Human, ELISA Kit - CSB-EL022829HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

stromal interaction molecule 1, ELISA Kit - MBS928508 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human STIM1 is typically less than 11.7 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 47 pg/ml -3000 pg/ml.

Human Stromal interaction molecule 1(STIM1) ELISA kit - CSB-EL022829HU from Cusabio Category ELISA Kit Sensitivity 11.7 pg/ml Range 47 pg/ml-3000 pg/ml

Human Stromal interaction molecule 1 (STIM1) ELISA Kit - EKC35674 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 11.7 pg/ml Range 47 pg/ml-3000 pg/ml

Human STIM1 ELISA Kit - E036810 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human STIM1 is typically less than 11.7 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

STIM1 ELISA Kit (Human) (OKCA00829) - OKCA00829 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 11.7 pg/mL Range 47 pg/mL-3,000 pg/mL

anti-STIM1 antibody [CDN3H4] - ARG63104 from Arigo Biolaboratories Category ELISA Kit

anti-STIM1 antibody - ARG56839 from Arigo Biolaboratories Category ELISA Kit

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