Gene Symbol | USP49 |
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Entrez Gene | 25862 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 49 |
Other Description | deubiquitinating enzyme 49|ubiquitin carboxyl-terminal hydrolase 49|ubiquitin specific protease 49|ubiquitin thioesterase 49|ubiquitin thiolesterase 49|ubiquitin-specific-processing protease 49 |
Swissprots | Q5T3D9 Q5T3E0 Q96CK4 Q70CQ1 |
Accessions | EAX04065 Q70CQ1 AJ586139 CAE51939 AK023682 AL110255 BC014176 AAH14176 BU631853 DN992189 EF565089 JF432543 ADZ15760 NM_001286554 NP_001273483 NM_018561 NP_061031 |
Function | Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. {ECO:0000269|PubMed:23824326}. |
Subcellular Location | Nucleus {ECO:0000305|PubMed:23824326}. |
USP49 (F-14) - sc-82409 from Santa Cruz Biotechnology
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USP49 (K-20) - sc-82411 from Santa Cruz Biotechnology
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USP49 (N-15) - sc-82412 from Santa Cruz Biotechnology
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Anti-USP49 antibody - ab108050 from Abcam
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Anti-USP49 antibody - ab127574 from Abcam
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Anti-USP49 antibody - ab194490 from Abcam
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Anti-USP49 Antibody (aa33-61, APC) - LS-C242508 from LifeSpan Bioscience
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Anti-USP49 Antibody (aa33-61, Biotin) - LS-C242509 from LifeSpan Bioscience
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Anti-USP49 Antibody (aa33-61, PE) - LS-C242511 from LifeSpan Bioscience
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Anti-USP49 Antibody (aa33-61, FITC) - LS-C242510 from LifeSpan Bioscience
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Anti-USP49 Antibody (aa33-61, Azide-free, HRP) - LS-C247206 from LifeSpan Bioscience
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Anti-USP49 Antibody (aa40-69) - LS-C326238 from LifeSpan Bioscience
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Anti-USP49 Antibody - LS-C332544 from LifeSpan Bioscience
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Anti-USP49 Antibody (aa33-61) - LS-C160478 from LifeSpan Bioscience
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Anti-USP49 Antibody (aa33-61, AP) - LS-C242506 from LifeSpan Bioscience
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USP49 Antibody - NBP1-81174 from Novus Biologicals
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USP49 Antibody - NBP1-81173 from Novus Biologicals
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USP49 Antibody - NBP2-20837 from Novus Biologicals
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USP49 Antibody - H00025862-A01 from Novus Biologicals
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Anti-USP49 antibody produced in rabbit - SAB2701420 from Sigma-Aldrich
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Anti-USP49 antibody produced in rabbit - HPA030255 from Sigma-Aldrich
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USP49 Antibody - N-terminal region (OAAB03347) - OAAB03347 from Aviva Systems Biology
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USP49-Antibody-N-term - AP5947a from Abgent, a WuXi AppTec company
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USP49 antibody - 70R-21215 from Fitzgerald
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USP49 Polyclonal Antibody - A3402 from ABclonal
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