| Gene Symbol | USP49 |
|---|---|
| Entrez Gene | 25862 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin specific peptidase 49 |
| Other Description | deubiquitinating enzyme 49|ubiquitin carboxyl-terminal hydrolase 49|ubiquitin specific protease 49|ubiquitin thioesterase 49|ubiquitin thiolesterase 49|ubiquitin-specific-processing protease 49 |
| Swissprots | Q5T3D9 Q5T3E0 Q96CK4 Q70CQ1 |
| Accessions | EAX04065 Q70CQ1 AJ586139 CAE51939 AK023682 AL110255 BC014176 AAH14176 BU631853 DN992189 EF565089 JF432543 ADZ15760 NM_001286554 NP_001273483 NM_018561 NP_061031 |
| Function | Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. {ECO:0000269|PubMed:23824326}. |
| Subcellular Location | Nucleus {ECO:0000305|PubMed:23824326}. |
ubiquitin specific peptidase 49, ELISA Kit - MBS9331998 from MyBioSource
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ubiquitin specific peptidase 49, ELISA Kit - MBS9332544 from MyBioSource
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Human USP49 ELISA Kit - E040344 from Biobool
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