| Gene Symbol |
USP49
|
| Entrez Gene |
25862
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 49
|
| Other Description |
deubiquitinating enzyme 49|ubiquitin carboxyl-terminal hydrolase 49|ubiquitin specific protease 49|ubiquitin thioesterase 49|ubiquitin thiolesterase 49|ubiquitin-specific-processing protease 49
|
| Swissprots |
Q5T3D9 Q5T3E0 Q96CK4 Q70CQ1
|
| Accessions |
EAX04065 Q70CQ1 AJ586139 CAE51939 AK023682 AL110255 BC014176 AAH14176 BU631853 DN992189 EF565089 JF432543 ADZ15760 NM_001286554 NP_001273483 NM_018561 NP_061031
|
| Function |
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. {ECO:0000269|PubMed:23824326}.
|
| Subcellular Location |
Nucleus {ECO:0000305|PubMed:23824326}.
|
![Western Blot: USP49 Overexpression Lysate (Adult Normal) [NBL1-17668] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for USP49.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1332_USP49%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17668-img0002.jpg)