Gene Symbol | USP49 |
---|---|
Entrez Gene | 25862 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 49 |
Other Description | deubiquitinating enzyme 49|ubiquitin carboxyl-terminal hydrolase 49|ubiquitin specific protease 49|ubiquitin thioesterase 49|ubiquitin thiolesterase 49|ubiquitin-specific-processing protease 49 |
Swissprots | Q5T3D9 Q5T3E0 Q96CK4 Q70CQ1 |
Accessions | EAX04065 Q70CQ1 AJ586139 CAE51939 AK023682 AL110255 BC014176 AAH14176 BU631853 DN992189 EF565089 JF432543 ADZ15760 NM_001286554 NP_001273483 NM_018561 NP_061031 |
Function | Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. {ECO:0000269|PubMed:23824326}. |
Subcellular Location | Nucleus {ECO:0000305|PubMed:23824326}. |
USP49 CRISPR/Cas9 KO Plasmid (h) - sc-411816 from Santa Cruz Biotechnology
|
||||||||
USP49 HDR Plasmid (h) - sc-411816-HDR from Santa Cruz Biotechnology
|
||||||||
USP49 Double Nickase Plasmid (h) - sc-411816-NIC from Santa Cruz Biotechnology
|
||||||||
USP49 Double Nickase Plasmid (h2) - sc-411816-NIC-2 from Santa Cruz Biotechnology
|
||||||||
USP49 CRISPR Activation Plasmid (h) - sc-411816-ACT from Santa Cruz Biotechnology
|
||||||||
USP49 CRISPR Activation Plasmid (h2) - sc-411816-ACT-2 from Santa Cruz Biotechnology
|
||||||||
USP49 Lentiviral Activation Particles (h) - sc-411816-LAC from Santa Cruz Biotechnology
|
||||||||
USP49 Lentiviral Activation Particles (h2) - sc-411816-LAC-2 from Santa Cruz Biotechnology
|
||||||||
USP49 siRNA (h) - sc-76867 from Santa Cruz Biotechnology
|
||||||||
USP49 shRNA Plasmid (h) - sc-76867-SH from Santa Cruz Biotechnology
|
||||||||
USP49 shRNA (h) Lentiviral Particles - sc-76867-V from Santa Cruz Biotechnology
|
||||||||
USP49 RNAi - H00025862-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU027951 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN22598 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22598 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR07663 from Sigma-Aldrich
|
||||||||
USP49 siRNA (Human) - CRH8550 from Cohesion Biosciences
|
||||||||
USP49 - MBS8235262 from MyBioSource
|
||||||||
shRNA set against Human USP49 (NM_018561.3) - SHH441700 from Creative biogene
|
||||||||
shRNA set against Human USP49(NM_018561.3) - SHL118656 from Creative biogene
|
||||||||
Human USP49 siRNA - orb269052 from Biorbyt
|
||||||||
USP49 shRNA Plasmid (Human) - CHH8550 from Cohesion Biosciences
|
||||||||
USP49 miRNA 3'UTR clone - MiUTR1H-11069 from Creative biogene
|