SERPINE1

Gene Symbol SERPINE1
Entrez Gene 5054
Alt Symbol PAI, PAI-1, PAI1, PLANH1
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Other Description endothelial plasminogen activator inhibitor|plasminogen activator inhibitor 1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1|serpin E1
Swissprots F8WD53 P05121 B7Z4S0
Accessions AAA60007 AAA60009 AAD45828 AAK60338 CAA31722 CAA31729 CAB51606 CAB51607 CAB51639 CAB51737 CAB51738 CAB51739 CAY56481 CBX47312 EAW50195 EAW50196 EAW50197 P05121 AI752990 AK293248 BAH11475 AK297728 BAH12656 AK298048 BAH12712 AK316225 BAH14596 BC005927 BC010860 AAH10860 BC020765 BF351821 C00767 CN309001 CN309016 CN309038 DQ890694 ABM81620 DQ893877 ABM84803 M14083 AAA60008 M16006 AAA60003 X04429 CAA28025 X04729 CAA28438 X04731 CAA28442 X04744 CAA28444 X12701 CAA31208 NM_000602 NP_000593 NM_001165413
Function Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. {ECO:0000269|PubMed:15853774}.
Subcellular Location Secreted.
Tissue Specificity Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
Top Pathways p53 signaling pathway, Complement and coagulation cascades, Chagas disease (American trypanosomiasis), Hippo signaling pathway

PAI-1 (D9C4) Rabbit mAb - 11907 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9C4
Western blot analysis of extracts from COS-7 and HUVEC cells using PAI-1 (D9C4) Rabbit mAb.

PAI-1 (C-9) - sc-5297 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAI-1 (C-9): sc-5297. Western blot analysis of PAI-1 expression in HUV-EC-C whole cell lysate.

PAI-1 (H-135) - sc-8979 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PAI-1 (H-135): sc-8979. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse lung tumor showing cytoplasmic staining.

PAI-1 (M-20) - sc-6644 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PAI-1 (M-20): sc-6644. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

PAI-1 (C-20) - sc-6642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PAI-1 (C-20): sc-6642. Western blot analysis of human recombinant PAI-1.

PAI-1 (TJA6) - sc-59636 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl supernatant
Host Mouse
Clonality Monoclonal
PAI-1 (TJA6): sc-59636. Western blot analysis of PAI-1 expression in non-transfected: sc-110760 (A) and human PAI-1 transfected: sc-111254 (B) 293 whole cell lysates.

PAI-1 (3A120) - sc-59633 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PAI-1 (3A120): sc-59633. Western blot analysis of human PAI-1 expression in HUV-EC-C whole cell lysate.

Anti-PAI1 antibody - ab66705 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab66705 staining PAI1 in MCF-7 cells treated with splitomicin (ab141120), by ICC/IF. Increase in PAI1 expression correlates with increased concentration of splitomicin, as described in literature.The cells were incubated at 37°C for 48 hours in media containing different concentrations of ab141120 (splitomicin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66705 (1 μg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue

Anti-PAI1 antibody - ab20562 from Abcam

Prices $387.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-PAI1 antibody - ab31280 from Abcam

Prices $388.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-PAI1 antibody (ab31280) at 0.1 µg/ml + Human Liver lysate at 35 µg

Anti-PAI1 antibody - ab14197 from Abcam

Host Goat
Clonality Polyclonal

Anti-PAI1 antibody - ab89581 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-PAI1 antibody (ab89581) at 1 µg/ml + Human spleen tissue lysate at 50 µg

Anti-PAI1 antibody - ab62384 from Abcam

Prices $359.00
Sizes 200 µg
Host Sheep
Clonality Polyclonal

Anti-PAI1 antibody [1D5] - ab125687 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D5
Anti-PAI1 antibody [1D5] (ab125687) at 1/500 dilution + Human PAI1 recombinant protein (amino acids 194-316)

Anti-PAI1 antibody [3A120] - ab20924 from Abcam

Prices $372.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 3A120

Anti-PAI1 antibody [3E529] - ab20286 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E529

Anti-PAI1 antibody (Biotin) - ab48366 from Abcam

Prices $372.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal

Anti-PAI1 antibody [I-3] - ab82218 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone I-3

Anti-SERPINE1 / PAI-1 Antibody - LS-C3396 from LifeSpan Bioscience

Prices $475.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal

Anti-SERPINE1 / PAI-1 Antibody - LS-C3397 from LifeSpan Bioscience

Prices $475.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal

Anti-SERPINE1 / PAI-1 Antibody - LS-C3398 from LifeSpan Bioscience

Prices $475.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal

Anti-SERPINE1 / PAI-1 Antibody - LS-C3399 from LifeSpan Bioscience

Prices $415.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-SERPINE1 / PAI-1 Antibody - LS-C3400 from LifeSpan Bioscience

Prices $315.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-SERPINE1 / PAI-1 Antibody - LS-C3401 from LifeSpan Bioscience

Prices $425.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-SERPINE1 / PAI-1 Antibody - LS-C3402 from LifeSpan Bioscience

Prices $425.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal
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