SERPINE1

Gene Symbol SERPINE1
Entrez Gene 5054
Alt Symbol PAI, PAI-1, PAI1, PLANH1
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Other Description endothelial plasminogen activator inhibitor|plasminogen activator inhibitor 1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1|serpin E1
Swissprots F8WD53 P05121 B7Z4S0
Accessions AAA60007 AAA60009 AAD45828 AAK60338 CAA31722 CAA31729 CAB51606 CAB51607 CAB51639 CAB51737 CAB51738 CAB51739 CAY56481 CBX47312 EAW50195 EAW50196 EAW50197 P05121 AI752990 AK293248 BAH11475 AK297728 BAH12656 AK298048 BAH12712 AK316225 BAH14596 BC005927 BC010860 AAH10860 BC020765 BF351821 C00767 CN309001 CN309016 CN309038 DQ890694 ABM81620 DQ893877 ABM84803 M14083 AAA60008 M16006 AAA60003 X04429 CAA28025 X04729 CAA28438 X04731 CAA28442 X04744 CAA28444 X12701 CAA31208 NM_000602 NP_000593 NM_001165413
Function Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. {ECO:0000269|PubMed:15853774}.
Subcellular Location Secreted.
Tissue Specificity Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
Top Pathways p53 signaling pathway, Complement and coagulation cascades, Chagas disease (American trypanosomiasis), Hippo signaling pathway

PAI-1 CRISPR/Cas9 KO Plasmid (h) - sc-400300 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAI-1 HDR Plasmid (h) - sc-400300-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAI-1 Double Nickase Plasmid (h) - sc-400300-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAI-1 Double Nickase Plasmid (h2) - sc-400300-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAI-1 CRISPR Activation Plasmid (h) - sc-400300-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAI-1 CRISPR Activation Plasmid (h2) - sc-400300-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAI-1 Lentiviral Activation Particles (h) - sc-400300-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAI-1 Lentiviral Activation Particles (h2) - sc-400300-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PAI-1 siRNA (h) - sc-36179 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PAI-1 shRNA Plasmid (h) - sc-36179-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PAI-1 shRNA (h) Lentiviral Particles - sc-36179-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU016891 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1759 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1759 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SERPINE1 siRNA (Human) - CRH3360 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Serpin E1/PAI-1 RNAi - H00005054-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SERPINE1 - MBS8208267 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SERPINE1 (NM_000602.4) - SHH405348 from Creative biogene

Category siRNA
Species Reactivities Human

Human SERPINE1 siRNA - orb263862 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SERPINE1 shRNA Plasmid (Human) - CHH3360 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SERPINE1 miRNA 3'UTR clone - MiUTR3H-01768 from Creative biogene

Species Reactivities Human

SERPINE1 miRNA 3'UTR clone - MiUTR3H-01769 from Creative biogene

Species Reactivities Human
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