| Gene Symbol |
SERPINE1
|
| Entrez Gene |
5054
|
| Alt Symbol |
PAI, PAI-1, PAI1, PLANH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
|
| Other Description |
endothelial plasminogen activator inhibitor|plasminogen activator inhibitor 1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1|serpin E1
|
| Swissprots |
F8WD53 P05121 B7Z4S0
|
| Accessions |
AAA60007 AAA60009 AAD45828 AAK60338 CAA31722 CAA31729 CAB51606 CAB51607 CAB51639 CAB51737 CAB51738 CAB51739 CAY56481 CBX47312 EAW50195 EAW50196 EAW50197 P05121 AI752990 AK293248 BAH11475 AK297728 BAH12656 AK298048 BAH12712 AK316225 BAH14596 BC005927 BC010860 AAH10860 BC020765 BF351821 C00767 CN309001 CN309016 CN309038 DQ890694 ABM81620 DQ893877 ABM84803 M14083 AAA60008 M16006 AAA60003 X04429 CAA28025 X04729 CAA28438 X04731 CAA28442 X04744 CAA28444 X12701 CAA31208 NM_000602 NP_000593 NM_001165413
|
| Function |
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. {ECO:0000269|PubMed:15853774}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
|
| Top Pathways |
p53 signaling pathway, Complement and coagulation cascades, Chagas disease (American trypanosomiasis), Hippo signaling pathway
|
