SERPINE1

Gene Symbol	SERPINE1
Entrez Gene	5054
Alt Symbol	PAI, PAI-1, PAI1, PLANH1
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Other Description	endothelial plasminogen activator inhibitor|plasminogen activator inhibitor 1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1|serpin E1
Swissprots	F8WD53 P05121 B7Z4S0
Accessions	AAA60007 AAA60009 AAD45828 AAK60338 CAA31722 CAA31729 CAB51606 CAB51607 CAB51639 CAB51737 CAB51738 CAB51739 CAY56481 CBX47312 EAW50195 EAW50196 EAW50197 P05121 AI752990 AK293248 BAH11475 AK297728 BAH12656 AK298048 BAH12712 AK316225 BAH14596 BC005927 BC010860 AAH10860 BC020765 BF351821 C00767 CN309001 CN309016 CN309038 DQ890694 ABM81620 DQ893877 ABM84803 M14083 AAA60008 M16006 AAA60003 X04429 CAA28025 X04729 CAA28438 X04731 CAA28442 X04744 CAA28444 X12701 CAA31208 NM_000602 NP_000593 NM_001165413
Function	Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. {ECO:0000269|PubMed:15853774}.
Subcellular Location	Secreted.
Tissue Specificity	Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
Top Pathways	p53 signaling pathway, Complement and coagulation cascades, Chagas disease (American trypanosomiasis), Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PAI1 (mutated ) full length protein - ab93149 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 (mutated N150 H + K154 T + Q319 L + M354 I) full length protein - ab92969 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 (mutated N150 H + K154 T + Q319 L + M354 I) full length protein - ab185275 from Abcam Category Protein Prices $1,023.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 (mutated S) full length protein - ab92830 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 (mutated S338) full length protein - ab92773 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 full length protein - ab184606 from Abcam Category Protein Prices $1,023.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 full length protein - ab92940 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 full length protein - ab92944 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 full length protein - ab92772 from Abcam Category Protein Prices $880.00 Sizes 500 µg Source Insect cells Species Human

Active human PAI1 full length protein - ab92870 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Human

Active human PAI1 full length protein - ab184605 from Abcam Category Protein Prices $1,398.00 Sizes 500 µg Source Insect cells Species Human

Active human PAI1 protein fragment - ab92871 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Human

Active mouse PAI1 (mutated I91) full length protein - ab93066 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Mouse

Active mouse PAI1 full length protein - ab93068 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Mouse

Active pig PAI1 full length protein - ab92866 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Pig

Active rabbit PAI1 (mutated I91 L) full length protein - ab119817 from Abcam Category Protein Prices $820.00 Sizes 500 µg Source E. coli Species Rabbit

Active rabbit PAI1 full length protein - ab92735 from Abcam Category Protein Prices $643.00 Sizes 100 µg Source E. coli Species Rabbit

Active rabbit PAI1 full length protein - ab92817 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Rabbit

Active rat PAI1 (mutated I91 L) full length protein - ab92835 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Rat

Active rat PAI1 full length protein - ab170082 from Abcam Category Protein Prices $880.00 Sizes 500 µg Source E. coli Species Rat

Active rat PAI1 full length protein - ab170081 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Rat

Active rat PAI1 full length protein - ab93012 from Abcam Category Protein Prices $643.00 Sizes 500 µg Source E. coli Species Rat

Active rat PAI1 full length protein - ab187232 from Abcam Category Protein Prices $1,398.00 Sizes 500 µg Source Insect cells Species Rat

Human PAI1 (mutated ) full length protein - ab93106 from Abcam Category Protein Source E. coli Species Human

Human PAI1 (mutated ) full length protein - ab92771 from Abcam Category Protein Source E. coli Species Human

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