HRG

Gene Symbol	HRG
Entrez Gene	3273
Alt Symbol	HPRG, HRGP, THPH11
Species	Human
Gene Type	protein-coding
Description	histidine-rich glycoprotein
Other Description	histidine-proline-rich glycoprotein
Swissprots	B9EK35 P04196 D3DNU7
Accessions	BAA21613 CAA78925 EAW78183 EAW78184 P04196 AI800281 AK313381 BAG36179 BC069574 AAH69574 BC150591 AAI50592 CR749302 CAH18157 DA637240 M13149 AAA52694 XM_005247415 XP_005247472 NM_000412 NP_000403
Function	Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the
Subcellular Location	Secreted {ECO:0000269|PubMed:21215706}.
Tissue Specificity	Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level). {ECO:0000269|PubMed:14744774, ECO:0000269|PubMed:19903770, ECO:0000269|PubMed:21215706}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HPRG (G-10) - sc-398239 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

HPRG (C-17) - sc-47042 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HPRG (N-13) - sc-47045 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-HRG antibody - ab198920 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-HRG antibody - ab83671 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HRG antibody - ab67807 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-HRG antibody [MM0331-6Z48] - ab89464 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0331-6Z48

Anti-HRG antibody - N-terminal - ab85209 from Abcam Prices $304.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa19-200) - LS-C344071 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (C-Terminus) IHC-plus™ - LS-B11467 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa93-328, Biotin) - LS-C299452 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa18-254, Biotin) - LS-C298032 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa18-254, FITC) - LS-C304451 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa93-328, FITC) - LS-C304452 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody - LS-C308247 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-HRG Antibody - LS-C310612 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-HRG Antibody - LS-C310613 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa93-328) - LS-C294516 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa287-336) - LS-C107611 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa18-254) - LS-C294512 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa106-302) - LS-C314916 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HRG Antibody (aa13-42) - LS-C100915 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

HPRG Antibody - AF1869 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Goat Clonality Polyclonal

HPRG Antibody - NBP2-33723 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HPRG Antibody - NBP2-33594 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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