HRG

Gene Symbol	HRG
Entrez Gene	3273
Alt Symbol	HPRG, HRGP, THPH11
Species	Human
Gene Type	protein-coding
Description	histidine-rich glycoprotein
Other Description	histidine-proline-rich glycoprotein
Swissprots	B9EK35 P04196 D3DNU7
Accessions	BAA21613 CAA78925 EAW78183 EAW78184 P04196 AI800281 AK313381 BAG36179 BC069574 AAH69574 BC150591 AAI50592 CR749302 CAH18157 DA637240 M13149 AAA52694 XM_005247415 XP_005247472 NM_000412 NP_000403
Function	Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the
Subcellular Location	Secreted {ECO:0000269|PubMed:21215706}.
Tissue Specificity	Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level). {ECO:0000269|PubMed:14744774, ECO:0000269|PubMed:19903770, ECO:0000269|PubMed:21215706}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HRG cDNA clone(NM_000412.2) - CDFH008772 from Creative Biomart Species Human Accession NM_000412.2

Human HRG ORF Clone(NM_000412.2) - CDCR336181 from Creative Biomart Species Human Accession NM_000412.2

Human HRG ORF Clone(NM_000412.2) - CDCR336182 from Creative Biomart Species Human Accession NM_000412.2

Human HRG ORF Clone(NM_000412.2) - CDCR336183 from Creative Biomart Species Human Accession NM_000412.2

Human HRG ORF clone(NM_000412.2) - CDCR007267 from Creative Biomart Species Human Accession NM_000412.2

Human HRG ORF Clone(NM_000412.2) - CDCL166479 from Creative Biomart Species Human Accession NM_000412.2

Human HPRG/HRG Gene ORF cDNA clone in cloning vector - HG10836-M from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, C-His tag - HG10836-CH from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10836-ACR from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10836-ACG from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid - HG10836-UT from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10836-NF from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10836-NM from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, C-HA tag - HG10836-CY from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10836-CF from Sino Biological Species Human

Human HRG / HPRG Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-tagged - HG10836-M-F from Sino Biological Species Human Accession NM_000412.2

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10836-CM from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, N-His tag - HG10836-NH from Sino Biological Species Human

Human HPRG/HRG Gene ORF cDNA clone expression plasmid, N-HA tag - HG10836-NY from Sino Biological Species Human

Human HPRG ORF clone(NM_000412.2) - CDCL184605 from Creative biogene Species Human

Human HRG cDNA Clone(NM_000412.2) - CDFH008772 from Creative biogene Species Human

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