| Gene Symbol |
HRG
|
| Entrez Gene |
3273
|
| Alt Symbol |
HPRG, HRGP, THPH11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histidine-rich glycoprotein
|
| Other Description |
histidine-proline-rich glycoprotein
|
| Swissprots |
B9EK35 P04196 D3DNU7
|
| Accessions |
BAA21613 CAA78925 EAW78183 EAW78184 P04196 AI800281 AK313381 BAG36179 BC069574 AAH69574 BC150591 AAI50592 CR749302 CAH18157 DA637240 M13149 AAA52694 XM_005247415 XP_005247472 NM_000412 NP_000403
|
| Function |
Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:21215706}.
|
| Tissue Specificity |
Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level). {ECO:0000269|PubMed:14744774, ECO:0000269|PubMed:19903770, ECO:0000269|PubMed:21215706}.
|
![Western Blot: HRG Overexpression Lysate (Adult Normal) [NBL1-11707] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HRG.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2664_HRG%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11707-img0002.jpg)