HRG

Gene Symbol	HRG
Entrez Gene	3273
Alt Symbol	HPRG, HRGP, THPH11
Species	Human
Gene Type	protein-coding
Description	histidine-rich glycoprotein
Other Description	histidine-proline-rich glycoprotein
Swissprots	B9EK35 P04196 D3DNU7
Accessions	BAA21613 CAA78925 EAW78183 EAW78184 P04196 AI800281 AK313381 BAG36179 BC069574 AAH69574 BC150591 AAI50592 CR749302 CAH18157 DA637240 M13149 AAA52694 XM_005247415 XP_005247472 NM_000412 NP_000403
Function	Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the
Subcellular Location	Secreted {ECO:0000269|PubMed:21215706}.
Tissue Specificity	Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level). {ECO:0000269|PubMed:14744774, ECO:0000269|PubMed:19903770, ECO:0000269|PubMed:21215706}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HRG-Antibody-N-term-Blocking-Peptide - BP7327a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human HPRG, CF - 1869-HP-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Val19-Lys525, with a C-terminal 10-His tag

Human HRG Protein - abx067113 from Abbexa Category Protein Source E.coli Species Human

Histidine-rich glycoprotein / HRG - H00003273-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Histidine Rich Glycoprotein (HRG), Human - 20-8519 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

HRG fusion protein - ag16278 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human HRG, His tagged - HRG-753H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human Histidine-Rich Glycoprotein - HRG-332H from Creative Biomart Category Protein Source E. coli.

HPRG / HRG - PN201678 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Recombinant Histidine Rich Glycoprotein (HRG) - RPC534Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Histidine Rich Glycoprotein (HRG) - RPC534Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Histidine Rich Glycoprotein (HRG) - RPC534Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Histidine Rich Glycoprotein (HRG) - RPC534Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Human HPRG / HRG Protein (His Tag) - 10836-H08H-20 from Sino Biological Category Protein Prices $138.00, $298.00 Sizes 20 µg, 50 µg Source Human Cells Species Human

Recombinant Histidine Rich Glycoprotein (HRG) - RPC534Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Histidine-rich glycoprotein(HRG) - CSB-YP010736HU CSB-EP010736HU CSB-BP010736HU CSB-MP010736HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human HPRG Protein, CF - 1869-HP from R&D Systems Category Protein Prices $329.00 Sizes 25 µg Source Mouse myeloma cell line, NS0-derived Val19-Lys525, with a C-terminal 10-His tag Species Human

HRG Protein - abx163601 from Abbexa Category Protein Species Mouse

Histidine-rich glycoprotein / HRG - TP310166 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human HPRG / HRG Protein (His tag) - PKSH031403 from Elabscience Category Protein Source Human Cells Species Human

Human HPRG / HRG Protein (His Tag) - 10836-H08H-100 from Sino Biological Category Protein Source Human Cells Species Human

HRG Recombinant Protein (OPCD03980) - OPCD03980 from Aviva Systems Biology Category Protein Source E.coli Species Human

Human HPRG / HRG Protein (His Tag) - 10836-H08H from ABclonal Category Protein Prices $138.00, $298.00, $348.00 Sizes 20 µg, 50 µg, 100 µg Source Human Cells Species Human

Histidine Rich Glycoprotein (HRG), Recombinant Protein - MBS2010965 from MyBioSource Category Protein Prices $190.00, $405.00, $625.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Histidine-rich glycoprotein, Recombinant Protein - MBS1033026 from MyBioSource Category Protein Prices $1,060.00, $1,060.00, $1,290.00, $1,290.00, $1,655.00, $1,655.00, $2,120.00, $2,120.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

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