VKORC1

Gene Symbol	VKORC1
Entrez Gene	79001
Alt Symbol	EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Species	Human
Gene Type	protein-coding
Description	vitamin K epoxide reductase complex, subunit 1
Other Description	phylloquinone epoxide reductase|vitamin K dependent clotting factors deficiency 2|vitamin K epoxide reductase complex subunit 1|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive)
Swissprots	Q7Z2R4 A6NIQ6 B2R4Z6 Q6UX90 Q9BQB6
Accessions	AAS83106 ACG63771 ACZ98832 ACZ98833 AJE63370 AJE63371 CAP58832 EAW52165 EAW52166 EAW52167 EAW52168 Q9BQB6 AF176924 AAQ13668 AK125618 BAC86222 AK129513 AK289790 BAF82479 AK312005 BAG34943 AY423044 AAR82914 AY466113 AAR28759 AY521634 AAS01052 BC000828 BC002911 AAH02911 BI822140 CD249837 JF432549 ADZ15766 XM_011545943 XP_011544245 XM_011545944 XP_011544246 XM_011545945 XP_011544247 XR_950848 NM_024006 NP_076869 NM_206824 NP_996560
Function	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:14765195, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Tissue Specificity	Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas. {ECO:0000269|PubMed:14765194}.
Top Pathways	Ubiquinone and other terpenoid-quinone biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Anti-VKORC1 antibody - ab108053 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 antibody - N-terminal - ab176118 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa15-41, AP) - LS-C273336 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa15-41, APC) - LS-C273337 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa15-41, Biotin) - LS-C273338 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa15-41, FITC) - LS-C273339 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa15-41, Azide-free, HRP) - LS-C273340 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa15-41, PE) - LS-C273341 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa22-49) - LS-C326281 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa27-76) - LS-C169733 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (aa15-41) - LS-C160531 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 Antibody (N-Terminus) - LS-C153685 from LifeSpan Bioscience Prices $345.00, $1,035.00 Sizes 100 µg, 500 µg Host Rabbit Clonality Polyclonal

VKORC1 Antibody - NBP1-92573 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-VKORC1 (N-TERM) antibody produced in rabbit - SAB1301480 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-VKORC1 antibody produced in rabbit - HPA042720 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

VKORC1 Antibody - N-terminal region (ARP63330_P050) - ARP63330_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

VKORC1 Antibody - N-terminal region (OAAB03260) - OAAB03260 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

VKORC1-Antibody-N-term - AP5859a from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

VKORC1 antibody - orb75780 from Biorbyt Prices $723.00 Sizes 100 μg Host Rabbit Clonality Polyclonal

VKORC1 (N-term) antibody - AP55645PU-N from Acris Antibodies Prices $340.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

VKORC1 Antibody - 6795 from ProSci Prices $79.00, $325.00 Sizes 20 µg, 100 µg Host Rabbit Clonality Polyclonal

VKORC1 Antibody - 25474 from Signalway Antibody Prices $390.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-VKORC1 monoclonal antibody - DCABH-13963 from Creative Diagnostics Host Rabbit Clonality Monoclonal

Anti-VKORC1 (N-terminal) polyclonal antibody - DPABH-11850 from Creative Diagnostics Host Rabbit Clonality Polyclonal

Anti-VKORC1 (N-terminal) polyclonal antibody - DPAB-L21419 from Creative Diagnostics Host Rabbit Clonality Polyclonal

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