VKORC1

Gene Symbol	VKORC1
Entrez Gene	79001
Alt Symbol	EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Species	Human
Gene Type	protein-coding
Description	vitamin K epoxide reductase complex, subunit 1
Other Description	phylloquinone epoxide reductase|vitamin K dependent clotting factors deficiency 2|vitamin K epoxide reductase complex subunit 1|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive)
Swissprots	Q7Z2R4 A6NIQ6 B2R4Z6 Q6UX90 Q9BQB6
Accessions	AAS83106 ACG63771 ACZ98832 ACZ98833 AJE63370 AJE63371 CAP58832 EAW52165 EAW52166 EAW52167 EAW52168 Q9BQB6 AF176924 AAQ13668 AK125618 BAC86222 AK129513 AK289790 BAF82479 AK312005 BAG34943 AY423044 AAR82914 AY466113 AAR28759 AY521634 AAS01052 BC000828 BC002911 AAH02911 BI822140 CD249837 JF432549 ADZ15766 XM_011545943 XP_011544245 XM_011545944 XP_011544246 XM_011545945 XP_011544247 XR_950848 NM_024006 NP_076869 NM_206824 NP_996560
Function	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:14765195, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Tissue Specificity	Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas. {ECO:0000269|PubMed:14765194}.
Top Pathways	Ubiquinone and other terpenoid-quinone biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VKORC1 ELISA Kit (Sandwich ELISA) - LS-F12957 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 0.78-50 ng/ml

Bovine VKORC1 ELISA Kit (Competitive EIA) - LS-F12956 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.78 Range 0.78-50 ng/ml

Vitamin K epoxide reductase complex subunit 1, VKORC1, Human, ELISA Kit - E0505h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1), ELISA Kit - MBS2025112 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.57ng/mL. Range 1.56-100ng/mL

ELISA Kit for Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) - SEG899Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.57ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) - SEG899Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.57ng/mL. Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Mouse VKORC1 ELISA Kit (Custom ELISA) - LS-F14672 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Rat VKORC1 ELISA Kit (Custom ELISA) - LS-F14673 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Human Vitamin K epoxide reductase complex subunit 1 ELISA Kit - abx253885 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human Vitamin K Epoxide Reductase Complex Subunit 1 ELISA Kit - abx156867 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human VKORC1 ELISA Kit (Sandwich ELISA) - LS-F25522 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.57 ng/ml Range 0.78-50 ng/ml

Human Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) ELISA Kit - EKU09239 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.57 ng/mL Range 1.56-100 ng/mL

Human Vitamin K epoxide reductase complex subunit 1 ELISA Kit - EKE51786 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 34 pg/mL Range 78-5000 pg/mL

VKORC1 - EKH1858 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

VKORC1 ELISA Kit (Human) : 96 Wells (OKEH00482) - OKEH00482 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 34 pg/mL Range 78.0 - 5,000 pg/mL

Human VKORC1 ELISA Kit - E040361 from Biobool Category ELISA Kit Sensitivity <46.9pg/ml

Human Vitamin K epoxide reductase complex subunit 1 ELISA Kit - EK1848 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 34pg/mL Range 78-5000 pg/mL

Vitamin K epoxide reductase complex subunit 1, ELISA Kit - MBS9425703 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 34pg/mL Range 78-5000 pg/mL

Vitamin K epoxide reductase complex subunit 1, ELISA Kit - MBS2882517 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78-5000 pg/mL

Human VKORC1 ELISA Kit (Sandwich ELISA) - LS-F33862 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 0.78-50 ng/ml

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