VKORC1

Gene Symbol	VKORC1
Entrez Gene	79001
Alt Symbol	EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Species	Human
Gene Type	protein-coding
Description	vitamin K epoxide reductase complex, subunit 1
Other Description	phylloquinone epoxide reductase|vitamin K dependent clotting factors deficiency 2|vitamin K epoxide reductase complex subunit 1|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive)
Swissprots	Q7Z2R4 A6NIQ6 B2R4Z6 Q6UX90 Q9BQB6
Accessions	AAS83106 ACG63771 ACZ98832 ACZ98833 AJE63370 AJE63371 CAP58832 EAW52165 EAW52166 EAW52167 EAW52168 Q9BQB6 AF176924 AAQ13668 AK125618 BAC86222 AK129513 AK289790 BAF82479 AK312005 BAG34943 AY423044 AAR82914 AY466113 AAR28759 AY521634 AAS01052 BC000828 BC002911 AAH02911 BI822140 CD249837 JF432549 ADZ15766 XM_011545943 XP_011544245 XM_011545944 XP_011544246 XM_011545945 XP_011544247 XR_950848 NM_024006 NP_076869 NM_206824 NP_996560
Function	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:14765195, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Tissue Specificity	Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas. {ECO:0000269|PubMed:14765194}.
Top Pathways	Ubiquinone and other terpenoid-quinone biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VKORC1 full length protein - ab153503 from Abcam Category Protein Source Wheat germ Species Human

VKORC1 Antibody Blocking Peptide - LS-E8011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VKORC1 Antibody Blocking Peptide - LS-E31259 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human VKORC1 Protein - H00079001-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

VKORC1-Antibody-N-term-Blocking-peptide - BP5859a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VKORC1 - H00079001-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VKORC1 - H00079001-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VKORC1 (N-term) Control Peptide - AP55645CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

VKORC1 Peptide - 6795P from ProSci Category Peptide Species Human

VKORC1 fusion protein - ag14060 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

VKORC1 fusion protein - ag14378 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

VKORC1 (transcript variant 2) - TP314831 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

VKORC1 Protein - NBP1-92573PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

VKORC1 Peptide, Human - M34GP17285H from Creative Peptides Category Peptide Source Synthetic. Species Human

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