| Gene Symbol |
VKORC1
|
| Entrez Gene |
79001
|
| Alt Symbol |
EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vitamin K epoxide reductase complex, subunit 1
|
| Other Description |
phylloquinone epoxide reductase|vitamin K dependent clotting factors deficiency 2|vitamin K epoxide reductase complex subunit 1|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive)
|
| Swissprots |
Q7Z2R4 A6NIQ6 B2R4Z6 Q6UX90 Q9BQB6
|
| Accessions |
AAS83106 ACG63771 ACZ98832 ACZ98833 AJE63370 AJE63371 CAP58832 EAW52165 EAW52166 EAW52167 EAW52168 Q9BQB6 AF176924 AAQ13668 AK125618 BAC86222 AK129513 AK289790 BAF82479 AK312005 BAG34943 AY423044 AAR82914 AY466113 AAR28759 AY521634 AAS01052 BC000828 BC002911 AAH02911 BI822140 CD249837 JF432549 ADZ15766 XM_011545943 XP_011544245 XM_011545944 XP_011544246 XM_011545945 XP_011544247 XR_950848 NM_024006 NP_076869 NM_206824 NP_996560
|
| Function |
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:14765195, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
|
| Tissue Specificity |
Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas. {ECO:0000269|PubMed:14765194}.
|
| Top Pathways |
Ubiquinone and other terpenoid-quinone biosynthesis
|