VKORC1

Gene Symbol VKORC1
Entrez Gene 79001
Alt Symbol EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Species Human
Gene Type protein-coding
Description vitamin K epoxide reductase complex, subunit 1
Other Description phylloquinone epoxide reductase|vitamin K dependent clotting factors deficiency 2|vitamin K epoxide reductase complex subunit 1|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive)
Swissprots Q7Z2R4 A6NIQ6 B2R4Z6 Q6UX90 Q9BQB6
Accessions AAS83106 ACG63771 ACZ98832 ACZ98833 AJE63370 AJE63371 CAP58832 EAW52165 EAW52166 EAW52167 EAW52168 Q9BQB6 AF176924 AAQ13668 AK125618 BAC86222 AK129513 AK289790 BAF82479 AK312005 BAG34943 AY423044 AAR82914 AY466113 AAR28759 AY521634 AAS01052 BC000828 BC002911 AAH02911 BI822140 CD249837 JF432549 ADZ15766 XM_011545943 XP_011544245 XM_011545944 XP_011544246 XM_011545945 XP_011544247 XR_950848 NM_024006 NP_076869 NM_206824 NP_996560
Function Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:14765195, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Tissue Specificity Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas. {ECO:0000269|PubMed:14765194}.
Top Pathways Ubiquinone and other terpenoid-quinone biosynthesis

VKORC1 CRISPR/Cas9 KO Plasmid (h) - sc-413104 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VKORC1 HDR Plasmid (h) - sc-413104-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VKORC1 Double Nickase Plasmid (h) - sc-413104-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VKORC1 Double Nickase Plasmid (h2) - sc-413104-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VKORC1 CRISPR Activation Plasmid (h) - sc-413104-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VKORC1 CRISPR Activation Plasmid (h2) - sc-413104-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VKORC1 Lentiviral Activation Particles (h) - sc-413104-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VKORC1 Lentiviral Activation Particles (h2) - sc-413104-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VKORC1 siRNA (h) - sc-106693 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VKORC1 shRNA Plasmid (h) - sc-106693-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VKORC1 shRNA (h) Lentiviral Particles - sc-106693-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU122741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22689 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22689 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02976 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02976

VKORC1 siRNA (Human) - CRJ2245 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VKORC1 - MBS8235249 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human VKORC1 (NM_024006.4) - SHH442824 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human VKORC1(NM_206824.1) - SHL126198 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human VKORC1(NM_024006.4) - SHL126216 from Creative biogene

Category siRNA
Species Reactivities Human

Human VKORC1 siRNA - orb272746 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VKORC1 shRNA Plasmid (Human) - CHJ2245 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

VKORC1 miRNA 3'UTR clone - MiUTR1H-11122 from Creative biogene

Species Reactivities Human

VKORC1 miRNA 3'UTR clone - MiUTR1H-11123 from Creative biogene

Species Reactivities Human
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