VKORC1

Gene Symbol VKORC1
Entrez Gene 79001
Alt Symbol EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Species Human
Gene Type protein-coding
Description vitamin K epoxide reductase complex, subunit 1
Other Description phylloquinone epoxide reductase|vitamin K dependent clotting factors deficiency 2|vitamin K epoxide reductase complex subunit 1|vitamin K1 2,3-epoxide reductase subunit 1|vitamin K1 epoxide reductase (warfarin-sensitive)
Swissprots Q7Z2R4 A6NIQ6 B2R4Z6 Q6UX90 Q9BQB6
Accessions AAS83106 ACG63771 ACZ98832 ACZ98833 AJE63370 AJE63371 CAP58832 EAW52165 EAW52166 EAW52167 EAW52168 Q9BQB6 AF176924 AAQ13668 AK125618 BAC86222 AK129513 AK289790 BAF82479 AK312005 BAG34943 AY423044 AAR82914 AY466113 AAR28759 AY521634 AAS01052 BC000828 BC002911 AAH02911 BI822140 CD249837 JF432549 ADZ15766 XM_011545943 XP_011544245 XM_011545944 XP_011544246 XM_011545945 XP_011544247 XR_950848 NM_024006 NP_076869 NM_206824 NP_996560
Function Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:14765195, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.
Tissue Specificity Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas. {ECO:0000269|PubMed:14765194}.
Top Pathways Ubiquinone and other terpenoid-quinone biosynthesis

VKORC1-Over-expression-Lysate - LY14310a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag VKORC1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the VKORC1 gene.

VKORC1 overexpression lysate - LY404226 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

VKORC1 overexpression lysate - LY430947 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

VKORC1 293 Cell Lysate - 402581 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

VKORC1 Overexpression Lysate (Native) - NBL1-17727 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: VKORC1 Overexpression Lysate (Adult Normal) [NBL1-17727] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VKORC1.

VKORC1 Over-expression Lysate Product - GWB-3852E5 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

VKORC1 Overexpression Lysate (Native) - NBP2-10124 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: VKORC1 Overexpression Lysate (Adult Normal) [NBP2-10124] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VKORC1.

Panoply™ Human VKORC1 Knockdown Stable Cell Line - CSC-DC017285 from Creative biogene

Category Cell Line
Species Human

Human VKORC1 Knockout Cell Line-HeLa - CSC-RT0878 from Creative biogene

Category Cell Line
Species Human

Human VKORC1 Knockout Cell Line-HEK293T - CSC-RT1206 from Creative biogene

Category Cell Line
Species Human

VKORC1 KO Cell Lysate-HeLa - CLKO-0378 from Creative biogene

Category Cell Lysate

VKORC1 KO Cell Lysate-HEK293T - CLKO-1059 from Creative biogene

Category Cell Lysate
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