Gene Symbol | HEXIM1 |
---|---|
Entrez Gene | 10614 |
Alt Symbol | CLP1, EDG1, HIS1, MAQ1 |
Species | Human |
Gene Type | protein-coding |
Description | hexamethylene bis-acetamide inducible 1 |
Other Description | HMBA-inducible|cardiac lineage protein 1|estrogen down-regulated gene 1 protein|hexamethylene bis-acetamide-inducible protein 1|hexamethylene bisacetamide-inducible protein|hexamethylene-bis-acetamide-inducible transcript 1|hexamthylene bis-acetamide inducible 1|menage a quatre 1|menage a quatre protein 1|protein HEXIM1 |
Swissprots | O94992 B2R8Y5 |
Accessions | O94992 AB021179 BAA36166 AI092623 AK023624 BAG51211 AK313557 BAG36332 AL521530 AL562001 AW881781 BC006460 AAH06460 BQ777682 BX111838 CA448958 CA946973 CV810471 DB539383 DQ893272 ABM84198 DQ896158 ABM87157 DQ896603 ABM87602 NM_006460 NP_006451 |
Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:12941847, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Binds alpha- importin and is mostly nuclear. |
Tissue Specificity | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. {ECO:0000269|PubMed:12941847, ECO:0000269|PubMed:15713661}. |
hexamethylene bis-acetamide inducible 1, ELISA Kit - MBS927310 from MyBioSource
|
||||||||||
Human Protein HEXIM1(HEXIM1) ELISA kit - CSB-EL010318HU from Cusabio
|
||||||||||
Human Protein HEXIM1 (HEXIM1) ELISA Kit - EKC35212 from Biomatik
|
||||||||||
Human HEXIM1 ELISA Kit - E018537 from Biobool
|
||||||||||
HEXIM1 ELISA Kit (Human) (OKCA00778) - OKCA00778 from Aviva Systems Biology
|
||||||||||
anti-HEXIM1 antibody - ARG64108 from Arigo Biolaboratories
|
||||||||||
HEXIM1, ELISA Kit - MBS284026 from MyBioSource
|
||||||||||
Human HEXIM1 ELISA Kit - orb405119 from Biorbyt
|
||||||||||