TNFSF18

Gene Symbol TNFSF18
Entrez Gene 8995
Alt Symbol AITRL, GITRL, TL6, hGITRL
Species Human
Gene Type protein-coding
Description tumor necrosis factor (ligand) superfamily, member 18
Other Description AITR ligand|GITR ligand|activation-inducible TNF-related ligand|glucocorticoid-induced TNF-related ligand|glucocorticoid-induced TNFR-related protein ligand|tumor necrosis factor ligand superfamily member 18
Swissprots Q6ISV1 A9IQG8 Q9UNG2 O95852
Accessions CAI38637 EAW90937 Q9UNG2 AF117713 AAD19695 AF125303 AAD22634 AK313273 BAG36082 AY358868 AAQ89227 BC069111 AAH69111 BC069319 AAH69319 BC093986 AAH93986 BC112032 AAI12033 BX473859 NM_005092 NP_005083
Function Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
Tissue Specificity Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Top Pathways Cytokine-cytokine receptor interaction

GITRL (T-15) - sc-5762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GITRL (T-15): sc-5762. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

GITRL (C-18) - sc-5764 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GITRL (EB11) - sc-53973 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

GITRL (FL-177) - sc-66906 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-TNFSF18 antibody - ab25948 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TNFSF18 antibody (ab25948) at 1 µg/mlLane 1 : 5ng of purified recombinant TNFSF18 Lane 2 : 25ng of purified recombinant TNFSF18 Lane 3 : 50ng of purified recombinant TNFSF18

Anti-TNFSF18 antibody - ab124195 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TNFSF18 antibody (ab124195) at 1/100 dilutionLane 1 : 293 cell line lysates - non transfectedLane 2 : 293 cell line lysates - transiently transfected with the TNFSF18 geneLysates/proteins at 2 µg per lane.

Anti-TNFSF18 antibody - ab56352 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56352 TNFSF18 antibody at 1ug/ml.

Anti-TNFSF18 antibody - ab109828 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFSF18 antibody (Biotin) - ab84236 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFSF18 antibody [MM0312-4Q25] - ab89340 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0312-4Q25

Anti-TNFSF18 / GITRL Antibody - LS-C7099 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFSF18 / GITRL Antibody - LS-C7101 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFSF18 / GITRL Antibody (Biotin) - LS-C7100 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFSF18 / GITRL Antibody - LS-C7102 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Polyclonal

Anti-TNFSF18 / GITRL Antibody - LS-C7103 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rat
Clonality Monoclonal

Anti-TNFSF18 / GITRL Antibody (aa47-173) - LS-C36435 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Rat
Clonality Monoclonal

Anti-TNFSF18 / GITRL Antibody - LS-C129247 from LifeSpan Bioscience

Prices $530.00
Sizes 250 µg
Host Rat
Clonality Monoclonal

Anti-TNFSF18 / GITRL Antibody - LS-C129248 from LifeSpan Bioscience

Host Rat
Clonality Monoclonal

Anti-TNFSF18 / GITRL Antibody - LS-C129249 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-TNFRSF18 / GITR Antibody (clone 11E203, APC) - LS-C183881 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 11E203

Anti-TNFSF18 / GITRL Antibody (Biotin) - LS-C104680 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFRSF18 / GITR Antibody (clone 11E203, PE) - LS-C183883 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 11E203

Anti-TNFRSF18 / GITR Antibody (clone 11n78, APC) - LS-C184764 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Rat
Clonality Monoclonal
Clone 11n78

Anti-TNFRSF18 / GITR Antibody (clone 11E203, FITC) - LS-C183882 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 11E203

Anti-TNFSF18 / GITRL Antibody (Extracellular Domain, clone 11n77, PerCP) - LS-C184762 from LifeSpan Bioscience

Prices $575.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 11n77
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