TNFSF18

Gene Symbol	TNFSF18
Entrez Gene	8995
Alt Symbol	AITRL, GITRL, TL6, hGITRL
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 18
Other Description	AITR ligand|GITR ligand|activation-inducible TNF-related ligand|glucocorticoid-induced TNF-related ligand|glucocorticoid-induced TNFR-related protein ligand|tumor necrosis factor ligand superfamily member 18
Swissprots	Q6ISV1 A9IQG8 Q9UNG2 O95852
Accessions	CAI38637 EAW90937 Q9UNG2 AF117713 AAD19695 AF125303 AAD22634 AK313273 BAG36082 AY358868 AAQ89227 BC069111 AAH69111 BC069319 AAH69319 BC093986 AAH93986 BC112032 AAI12033 BX473859 NM_005092 NP_005083
Function	Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
Tissue Specificity	Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-TNFSF18-cDNA-Clone - DC08701 from Abgent, a WuXi AppTec company Prices $238.95 Sizes 10 µg Species Human Accession BC093986

Rat GITR Ligand/TNFSF18 (XP_008767927) VersaClone cDNA - RDC1159 from R&D Systems Prices $199.00 Sizes 10 µg Species Rat

TNFSF18 - MBS1267964 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC069319

Human TNFSF18 cDNA clone(NM_005092.3) - CDFH020028 from Creative Biomart Species Human Accession NM_005092.3

Human TNFSF18 ORF Clone(NM_005092.3) - CDCR289573 from Creative Biomart Species Human Accession NM_005092.3

Human TNFSF18 ORF Clone(NM_005092.3) - CDCR289574 from Creative Biomart Species Human Accession NM_005092.3

Human TNFSF18 ORF Clone(NM_005092.3) - CDCR289575 from Creative Biomart Species Human Accession NM_005092.3

Human TNFSF18 ORF Clone(NM_005092.3) - CDCL179256 from Creative Biomart Species Human Accession NM_005092.3

Human TNFSF18 ORF Clone(NM_005092.3) - CDCL179257 from Creative Biomart Species Human Accession NM_005092.3

human TNFSF18 ORF clone - CDCH093622 from Creative Biomart Species Human Accession NM_005092

human TNFSF18 ORF clone - CDCH093623 from Creative Biomart Species Human Accession NM_005092

human TNFSF18 ORF clone - CDCH093624 from Creative Biomart Species Human Accession NM_005092

human TNFSF18 ORF clone - CDCH093625 from Creative Biomart Species Human Accession NM_005092

human TNFSF18 ORF clone - CDCH093626 from Creative Biomart Species Human Accession NM_005092

human TNFSF18 ORF clone - CDCH093627 from Creative Biomart Species Human Accession NM_005092

Human TNFSF18 Gene ORF cDNA clone in cloning vector - HG16080-G from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid, C-HA tag - HG16080-CY from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid, N-His tag - HG16080-NH from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG16080-ACG from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG16080-ACR from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid, N-HA tag - HG16080-NY from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG16080-NF from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid, C-His tag - HG16080-CH from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid - HG16080-UT from Sino Biological Species Human

Human TNFSF18 Gene ORF cDNA clone expression plasmid - HG13058-UT from Sino Biological Species Human

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