TNFSF18

Gene Symbol TNFSF18
Entrez Gene 8995
Alt Symbol AITRL, GITRL, TL6, hGITRL
Species Human
Gene Type protein-coding
Description tumor necrosis factor (ligand) superfamily, member 18
Other Description AITR ligand|GITR ligand|activation-inducible TNF-related ligand|glucocorticoid-induced TNF-related ligand|glucocorticoid-induced TNFR-related protein ligand|tumor necrosis factor ligand superfamily member 18
Swissprots Q6ISV1 A9IQG8 Q9UNG2 O95852
Accessions CAI38637 EAW90937 Q9UNG2 AF117713 AAD19695 AF125303 AAD22634 AK313273 BAG36082 AY358868 AAQ89227 BC069111 AAH69111 BC069319 AAH69319 BC093986 AAH93986 BC112032 AAI12033 BX473859 NM_005092 NP_005083
Function Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
Tissue Specificity Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Top Pathways Cytokine-cytokine receptor interaction

GITRL CRISPR/Cas9 KO Plasmid (h) - sc-405612 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GITRL HDR Plasmid (h) - sc-405612-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GITRL Double Nickase Plasmid (h) - sc-405612-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GITRL Double Nickase Plasmid (h2) - sc-405612-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GITRL CRISPR Activation Plasmid (h) - sc-405612-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GITRL CRISPR Activation Plasmid (h2) - sc-405612-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GITRL Lentiviral Activation Particles (h) - sc-405612-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GITRL Lentiviral Activation Particles (h2) - sc-405612-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GITRL siRNA (h) - sc-39827 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GITRL shRNA Plasmid (h) - sc-39827-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GITRL shRNA (h) Lentiviral Particles - sc-39827-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GITR Ligand/TNFSF18 RNAi - H00008995-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU120871 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21767 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21767 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TNFSF18 siRNA (Human) - CRH5936 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TNFSF18 - MBS8203135 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TNFSF18 (NM_005092.3) - SHH432172 from Creative biogene

Category siRNA
Species Reactivities Human

Human TNFSF18 siRNA - orb266438 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TNFSF18 shRNA Plasmid (Human) - CHH5936 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TNFSF18 miRNA 3'UTR clone - MiUTR1H-10610 from Creative biogene

Species Reactivities Human
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