| Gene Symbol |
TNFSF18
|
| Entrez Gene |
8995
|
| Alt Symbol |
AITRL, GITRL, TL6, hGITRL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor (ligand) superfamily, member 18
|
| Other Description |
AITR ligand|GITR ligand|activation-inducible TNF-related ligand|glucocorticoid-induced TNF-related ligand|glucocorticoid-induced TNFR-related protein ligand|tumor necrosis factor ligand superfamily member 18
|
| Swissprots |
Q6ISV1 A9IQG8 Q9UNG2 O95852
|
| Accessions |
CAI38637 EAW90937 Q9UNG2 AF117713 AAD19695 AF125303 AAD22634 AK313273 BAG36082 AY358868 AAQ89227 BC069111 AAH69111 BC069319 AAH69319 BC093986 AAH93986 BC112032 AAI12033 BX473859 NM_005092 NP_005083
|
| Function |
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
|
| Tissue Specificity |
Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
|
| Top Pathways |
Cytokine-cytokine receptor interaction
|
