TNFSF18

Gene Symbol	TNFSF18
Entrez Gene	8995
Alt Symbol	AITRL, GITRL, TL6, hGITRL
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 18
Other Description	AITR ligand|GITR ligand|activation-inducible TNF-related ligand|glucocorticoid-induced TNF-related ligand|glucocorticoid-induced TNFR-related protein ligand|tumor necrosis factor ligand superfamily member 18
Swissprots	Q6ISV1 A9IQG8 Q9UNG2 O95852
Accessions	CAI38637 EAW90937 Q9UNG2 AF117713 AAD19695 AF125303 AAD22634 AK313273 BAG36082 AY358868 AAQ89227 BC069111 AAH69111 BC069319 AAH69319 BC093986 AAH93986 BC112032 AAI12033 BX473859 NM_005092 NP_005083
Function	Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
Tissue Specificity	Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GITR Ligand (TNFSF18) Human ELISA Kit - ab113323 from Abcam Category ELISA Kit Prices $749.00 Sizes 1 x 96 tests Sensitivity < 25 pg/ml Range 41 pg/ml - 10000 pg/ml

Human GITR Ligand / TNFSF18 ELISA Kit - RAB0497 from Sigma-Aldrich Category ELISA Kit Prices $608.00 Sizes 1 kt

Human TNFSF18 / GITRL ELISA Kit (Sandwich ELISA) - LS-F97 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 40.96 pg/ml Range 40.96-4000 pg/ml

Mouse TNFSF18 / GITRL ELISA Kit (Sandwich ELISA) - LS-F244 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 4.096 pg/ml Range 40.96-4000 pg/ml

Mouse TNFSF18 / GITRL ELISA Kit (Sandwich ELISA) - LS-F2968 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 10 pg/ml Range 40.96-4000 pg/ml

Human TNFSF18 / GITRL ELISA Kit (Sandwich ELISA) - LS-F12796 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 40.96-4000 pg/ml

Human GITR Ligand/TNFSF18 DuoSet ELISA - DY694 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Mouse GITR Ligand/TNFSF18 DuoSet ELISA - DY2177 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Tumor necrosis factor ligand superfamily member 18 (TNFSF18), Human, ELISA Kit - CSB-EL023993HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Tumor necrosis factor ligand superfamily member 18, TNFSF18, Human, ELISA Kit - E8960h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 78-5000 pg/mL

TNFSF18 (Human) IP-WB Antibody Pair - H00008995-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TNFSF18 (Human) Matched Antibody Pair - H00008995-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TNFSF18 (Human) Matched Antibody Pair - H00008995-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TNFSF18 (Human) ELISA Kit - KA1721 from Acris Antibodies Category ELISA Kit Prices $780.00 Sizes 1 kit

Human GITR L ELISA - ELH-GITRL from RayBiotech Category ELISA Kit Prices $560.00, $1,008.00, $2,241.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 25 pg/ml Range 25 pg/ml - 10000 pg/ml

Human AITRL/TNFSF18(Activation-inducible TNF-related Ligand) ELISA Kit - E-EL-H5589 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

tumor necrosis factor (ligand) superfamily, member 18, ELISA Kit - MBS9311002 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

tumor necrosis factor (ligand) superfamily, member 18, ELISA Kit - MBS901664 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Tumor necrosis factor ligand superfamily member 18(TNFSF18) ELISA kit - CSB-EL023993HU from Cusabio Category ELISA Kit Sensitivity Request Information Range Request Information

Mouse TNFSF18 / GITRL ELISA Kit (Custom ELISA) - LS-F20259 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 40.96-4000 pg/ml

Human Tumor necrosis factor ligand superfamily member 18 ELISA Kit - abx252600 from Abbexa Category ELISA Kit Sensitivity 0.094 ng/ml Range 0.156 ng/ml - 10 ng/ml

Activation-inducible TNF-related Ligand�ELISA�Kit, AITRL/TNFSF18, Human, ELISA Kit - E-EL-H5589 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18) ELISA Kit - EKC35919 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.81 pg/ml Range 2000 pg/ml-31.25 pg/ml

Human Tumor necrosis factor ligand superfamily member 18 ELISA Kit - EKE54703 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 20 pg/mL Range 78-5000 pg/mL

TRAIL/TNFSF18 - EKH640 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

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