TNFSF18

Gene Symbol	TNFSF18
Entrez Gene	8995
Alt Symbol	AITRL, GITRL, TL6, hGITRL
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 18
Other Description	AITR ligand|GITR ligand|activation-inducible TNF-related ligand|glucocorticoid-induced TNF-related ligand|glucocorticoid-induced TNFR-related protein ligand|tumor necrosis factor ligand superfamily member 18
Swissprots	Q6ISV1 A9IQG8 Q9UNG2 O95852
Accessions	CAI38637 EAW90937 Q9UNG2 AF117713 AAD19695 AF125303 AAD22634 AK313273 BAG36082 AY358868 AAQ89227 BC069111 AAH69111 BC069319 AAH69319 BC093986 AAH93986 BC112032 AAI12033 BX473859 NM_005092 NP_005083
Function	Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
Tissue Specificity	Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TNFSF18 protein fragment - ab50093 from Abcam Category Protein Prices $110.00, $257.00 Sizes 5 µg, 20 µg Source E. coli Species Human

Human TNFSF18 protein fragment - ab113132 from Abcam Category Protein Source E. coli Species Human

Human TNFSF18 protein fragment - ab132518 from Abcam Category Protein Source Wheat germ Species Human

Human TNFSF18 protein fragment - ab196127 from Abcam Category Protein Source HEK 293 cells Species Human

Human TNFSF18 protein fragment - ab180272 from Abcam Category Protein Source E. coli Species Human

Human TNFSF18 protein fragment - ab182828 from Abcam Category Protein Source HEK 293 cells Species Human

Human TNFSF18 protein fragment - ab202190 from Abcam Category Protein Source E. coli Species Human

Human TNFSF18 protein fragment - ab85828 from Abcam Category Protein Source E. coli Species Human

Human TNFSF18 protein fragment - ab191726 from Abcam Category Protein Source E. coli Species Human

TNFSF18 / GITRL Antibody Blocking Peptide - LS-E4025 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFSF18 / GITRL Antibody Blocking Peptide - LS-E16957 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GITR Ligand/TNFSF18 Protein - NBP2-35053 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

GITR Ligand/TNFSF18 Recombinant Protein - H00008995-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GITR Ligand/TNFSF18 Partial Recombinant Protein - H00008995-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human GITR Ligand/TNFSF18 Protein - NBP1-72490 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

TNFSF18-Antibody-Center-Blocking-Peptide - BP16250c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GITRL Recombinant Protein (Active) - GTX48097-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

Recombinant Human GITR Ligand/TNFSF18 (CHO-expressed) - 6987-GL-025 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Recombinant Human GITR Ligand/TNFSF18 (CHO-expressed), CF - 6987-GL-025/CF from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Recombinant Human GITR Ligand/TNFSF18 - 694-GL-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Glu74-Ser199, with an N-terminal 6-His tag

Recombinant Human GITR Ligand/TNFSF18, CF - 694-GL-025/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Glu74-Ser199, with an N-terminal 6-His tag

CD4 Protein (OPPA00579) - OPPA00579 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

AITRL Protein (OPPA00580) - OPPA00580 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human AITRL protein - orb80255 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E.coli Species Human

Human AITRL protein - orb169453 from Biorbyt Category Protein Prices $187.00, $323.00, $5,372.00 Sizes 5 μg, 20 μg, 1 mg Source E.coli

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