Gene Symbol | TMEM30A |
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Entrez Gene | 55754 |
Alt Symbol | C6orf67, CDC50A |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein 30A |
Other Description | P4-ATPase flippase complex beta subunit TMEM30A|cell cycle control protein 50A |
Swissprots | Q658Z3 E1P539 Q9NV96 Q9NSL9 A8K9V8 Q96H09 |
Accessions | EAW48743 EAW48744 EAW48745 Q9NV96 AA599967 AJ420517 AK001718 BAA91859 AK022883 AK292823 BAF85512 AK293225 BAG56764 AK295567 BAG58467 AL162046 CAB82389 AL832490 CAH56205 AL832815 CAH56262 BC009006 AAH09006 DA217148 DB239737 HQ447873 ADQ32357 NM_001143958 NP_001137430 NM_018247 NP_060717 |
Function | Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8 |
Subcellular Location | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Apical cell membrane {ECO:0000250}. |
Cdc50A (Y-17) - sc-242402 from Santa Cruz Biotechnology
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Cdc50A (H-43) - sc-382155 from Santa Cruz Biotechnology
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Cdc50A (X-24) - sc-133449 from Santa Cruz Biotechnology
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Anti-TMEM30A Antibody (aa108-157) - LS-C81051 from LifeSpan Bioscience
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TMEM30A Antibody - NBP1-59474 from Novus Biologicals
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TMEM30A Antibody - NBP1-86739 from Novus Biologicals
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Transmembrane Protein 30A Antibody - bs-16576R from Bioss
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Anti-TMEM30A antibody produced in rabbit - AV47410 from Sigma-Aldrich
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TMEM30A Antibody - middle region (ARP47410_P050) - ARP47410_P050 from Aviva Systems Biology
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TMEM30A antibody - 70R-6371 from Fitzgerald
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TMEM30A Antibody - 30-282 from ProSci
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TMEM30A Antibody - GWB-MQ766A from Genway Biotech
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Anti-TMEM30A monoclonal antibody - DCABH-201613 from Creative Diagnostics
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Anti-TMEM30A (aa 108-157) polyclonal antibody - DPABH-21088 from Creative Diagnostics
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Transmembrane Protein 30A Antibody, Biotin Conjugated - bs-16576R-Biotin from Bioss
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Transmembrane Protein 30A Antibody, HRP Conjugated - bs-16576R-HRP from Bioss
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TMEM30A-Antibody-middle-region-AI12793 - AI12793 from Abgent, a WuXi AppTec company
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TMEM30A, Polyclonal Antibody - MBS5300614 from MyBioSource
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Anti-TMEM30A (N-terminal) polyclonal antibody - CABT-B920 from Creative Diagnostics
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TMEM30A / CDC50A antibody - TA342365 from Acris Antibodies
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Anti-Human TMEM30A Therapeutic Antibody (FC5) - TAB-712CT from Creative Biolabs
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Anti-Human TMEM30A Therapeutic Antibody Fab Fragment (FC5) - TAB-712CT-F(E) from Creative Biolabs
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Anti-Human TMEM30A Therapeutic Antibody scFv Fragment (FC5) - TAB-712CT-S(P) from Creative Biolabs
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Afuco™ Anti-Human TMEM30A ADCC Theraputic Antibody, ADCC Enhanced - AFC-596CL from Creative Biolabs
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Anti-Transmembrane Protein 30A Antibody A07121 - A07121 from Boster Bio
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