Gene Symbol | TLR5 |
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Entrez Gene | 7100 |
Alt Symbol | MELIOS, SLE1, SLEB1, TIL3 |
Species | Human |
Gene Type | protein-coding |
Description | toll-like receptor 5 |
Other Description | systemic lupus erythematosus susceptibility 1|toll/interleukin-1 receptor-like protein 3 |
Swissprots | O60602 D3DTB8 Q32MI3 B1AZ05 B9VJ63 B3Y633 D1CS80 O15456 Q32MI2 |
Accessions | AAZ17462 AAZ17463 AAZ17464 AAZ17465 AAZ17466 AAZ17467 AAZ17468 AAZ17469 AAZ17470 AAZ17471 AAZ17472 AAZ17473 ACM69017 ACM69018 ACM69019 ACM69020 ACM69021 ACM69022 ACM69023 ACM69024 ACM69025 ACM69026 ACM69027 ACM69028 ACM69029 ACM69030 ACM69031 ACM69032 ACM69033 ACM69034 EAW93262 EAW93263 O60602 AB060695 BAB43955 AB445645 BAG55042 AF051151 AAC34376 AI628024 BC109118 AAI09119 BC109119 AAI09120 BQ025528 DB448079 U88881 AAC34136 XM_005273241 XP_005273298 XM_005273242 XP_005273299 XM_005273243 XP_005273300 XM_006711504 XP_006711567 XM_006711505 XP_006711568 XM_006711506 XP_006711569 XM_011509937 XP_011508239 NM_003268 NP_003259 |
Function | Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:11323673}. |
Subcellular Location | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Tissue Specificity | Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis. |
Top Pathways | Toll-like receptor signaling pathway, Pathogenic Escherichia coli infection, Salmonella infection, Legionellosis, Inflammatory bowel disease (IBD) |
TLR5 (H-127) - sc-10742 from Santa Cruz Biotechnology |
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TLR5 (C-14) - sc-8696 from Santa Cruz Biotechnology |
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TLR5 (H-18) - sc-16243 from Santa Cruz Biotechnology |
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TLR5 (M-300) - sc-30003 from Santa Cruz Biotechnology
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TLR5 (N-15) - sc-8695 from Santa Cruz Biotechnology |
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TLR5 (85B152.5) - sc-52963 from Santa Cruz Biotechnology
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TLR5 (B-24) - sc-130897 from Santa Cruz Biotechnology
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TLR5 (19D759.2) - sc-57461 from Santa Cruz Biotechnology
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Anti-TLR5 antibody - ab62460 from Abcam
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Anti-TLR5 antibody - ab1654 from Abcam
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Anti-TLR5 antibody - ab37071 from Abcam
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Anti-TLR5 antibody - ab115603 from Abcam
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Anti-TLR5 antibody - ab156364 from Abcam
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Anti-TLR5 antibody - ab89497 from Abcam
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Anti-TLR5 antibody - ab13868 from Abcam
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Anti-TLR5 antibody [19D759.2] - ab13876 from Abcam
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Anti-TLR5 antibody [85B152.5] - ab13875 from Abcam
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Anti-TLR5 antibody [85B152.5] (FITC) - ab25929 from Abcam
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Anti-TLR5 antibody [85B152.5] (Phycoerythrin) - ab45119 from Abcam
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Anti-TLR5 antibody [EPR10373] - ab168382 from Abcam
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Anti-TLR5 Antibody (Internal) - LS-C10742 from LifeSpan Bioscience
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Anti-TLR5 Antibody (C-Terminus) - LS-C10743 from LifeSpan Bioscience
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Anti-TLR5 Antibody (C-Terminus) - LS-C10747 from LifeSpan Bioscience
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Anti-TLR5 Antibody (aa151-181) - LS-C83963 from LifeSpan Bioscience
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Anti-TLR5 Antibody - LS-C126384 from LifeSpan Bioscience
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