HTT

Gene Symbol HTT
Entrez Gene 3064
Alt Symbol HD, IT15
Species Human
Gene Type protein-coding
Description huntingtin
Other Description huntington disease protein
Swissprots Q9UQB7 P42858
Accessions ACJ05038 ACJ05039 ACJ05040 ACJ05043 ACJ05044 ACJ05045 ACJ05046 ACJ05047 ACJ05048 ACJ05049 ACJ05050 ACJ05051 ACJ05052 ACJ05053 ACJ05054 ACJ05055 ACJ05056 ACJ05057 ACJ05058 ACJ05059 ACJ05060 ACJ05061 ACJ05062 ACJ05064 CAA89024 CAA89025 CAA89839 EAW82474 EAW82475 EAW82476 EAW82477 EAW82478 P42858 AB016794 BAA36753 AB209506 BAD92743 AK025918 AK290544 BAF83233 BC014028 BC172756 AAI72756 KJ535072 AHW56711 L12392 AAB38240 L20431 AAA52702 NM_002111 NP_002102
Function May play a role in microtubule-mediated transport or vesicle function.
Subcellular Location Cytoplasm. Nucleus. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner.
Tissue Specificity Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation. {ECO:0000269|PubMed:16391387}.
Top Pathways Huntington's disease

Huntingtin (D7F7) XP ® Rabbit mAb - 5656 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7F7
Western blot analysis of extracts from rat and mouse brain tissue using Huntingtin (D7F7) XP ® Rabbit mAb.

Huntingtin Antibody - 2773 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from rat and mouse brain using Huntingtin Antibody.

Huntingtin (3E10) - sc-47757 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Huntingtin (3E10): sc-47757. Western blot analysis of Huntingtin expression in Jurkat whole cell lysate.

Huntingtin (4E10) - sc-47758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Huntingtin (4E10): sc-47758. Western blot analysis of Huntingtin expression in Jurkat whole cell lysate.

Huntingtin (C-20) - sc-8768 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Huntingtin (C-20): sc-8768. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing cytoplasmic staining of neuronal cells and glial cells.

Huntingtin (H-300) - sc-15352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Huntingtin (H-300): sc-15352. Western blot analysis of human recombinant Huntingtin fusion protein.

Huntingtin (N-18) - sc-8767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Huntingtin (N-18): sc-8767. Western blot analysis of Huntingtin expression in mouse brain extract.

Huntingtin (8A4) - sc-47759 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Huntingtin (8A4): sc-47759. Western blot analysis of Huntingtin expression in Jurkat whole cell lysate.

Huntingtin (3H2242) - sc-71287 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Huntingtin (3H2242): sc-71287. Western blot analysis of Huntingtin expression in Jurkat whole cell lysate.

Anti-Huntingtin (phospho S421) antibody - ab118827 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118827, at 10-20 µg/ml, staining Huntingtin (phospho S421) in formalin fixed, paraffin embedded Human brain cerebellum tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Huntingtin (phospho S421) antibody - ab2174 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Huntingtin (phospho S421) antibody (ab2174) at 1/1000 dilution + human PC-3 cell lysateObserved band size : 190 kDa (why is the actual band size different from the predicted?)Additional bands at : 120 kDa,130 kDa. We are unsure as to the identity of these extra bands.

Anti-Huntingtin (phospho S434) antibody - ab155931 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Huntingtin (phospho S434) antibody (ab155931) at 1/500 dilutionLane 1 : Lysate of 293T transfected with HuntingtinLane 2 : Lysate of 293T transfected with Huntingtin and treated with PPI inhibitorLane 3 : Lysate of 293T transfected with Huntingtin and treated with PPI inhibitor and CDK5SecondaryGoat anti-rabbit HRP conjugated antibody at 1/30000 dilutiondeveloped using the ECL technique

Anti-Huntingtin antibody - ab155942 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Huntingtin antibody (ab155942) at 1/500 dilutionLane 1 : -Lane 2 : +C2Lane 3 : +C3Lane 4 : +C6Lane 5 : +C7Lane 6 : Huntingtin23Q(1-513)Lane 7 : Huntingtin23Q(1-536)Lane 8 : Huntingtin23Q(1-552)Lane 9 : Huntingtin23Q(1-586)Lysates/proteins at 20 µg per lane.

Anti-Huntingtin antibody - ab155930 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sandwich ELISA was performed with a monoclonal antibody to Huntingtin and ab155930 to determine the antigen concentration of the Huntingtin cleavage products. The curve represents a dose response for neo586 in 293T cells overexpressing the Huntingtin construct.

Anti-Huntingtin antibody - ab76214 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Huntingtin antibody [1A771] - ab13583 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A771

Anti-Huntingtin antibody [2401C1a] - ab67092 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2401C1a
Anti-Huntingtin antibody [2401C1a] (ab67092) + immunising recombinant fragmentObserved band size : 35 kDa (why is the actual band size different from the predicted?)

Anti-Huntingtin antibody [EP867Y] - ab45169 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP867Y
Anti-Huntingtin antibody [EP867Y] (ab45169) at 1/10000 dilution + SH-SY-5Y cell lysate

Anti-Huntingtin antibody [EPR5526] - ab109115 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5526
All lanes : Anti-Huntingtin antibody [EPR5526] (ab109115) at 1/10000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HeLa cell lysateLane 3 : U87-MG cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Huntingtin antibody - C-terminal - ab83915 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Huntingtin antibody - C-terminal (ab83915) at 0.1 µg/mlLane 1 : mouse brain extractLane 2 : mouse brain extract with blocking peptide at 1 µg/ml

Anti-Huntingtin antibody - N-terminal - ab83916 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Huntingtin antibody - N-terminal (ab83916) at 0.1 µg/mlLane 1 : Mouse brain extractLane 2 : Mouse brain extract with blocking peptide at 1 µg/ml

Anti-HTT / Huntingtin Antibody (clone EP867Y) IHC-plus™ - LS-B9371 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EP867Y
Anti-HTT / Huntingtin antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTT / Huntingtin Antibody (phospho-Ser421) IHC-plus™ - LS-B36 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HTT / Huntingtin antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B36 concentration 20 ug/ml.

Anti-HTT / Huntingtin Antibody (aa1844-2131) - LS-C24585 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-HTT / Huntingtin Antibody (aa1247-1646) - LS-C24588 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Search more